About: Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pulsed laser deposition was proved as a suitable method for hydroxyapatite (HA) coating of coaxial poly-epsilon-aprolactone/polyvinylalcohol (PCL/PVA) nanofibers. The fibrous morphology of PCL/PVA nanofibers was preserved, if the nanofiber scaffold was coated with thin layers of HA (200nm and 400 nm). Increasing thickness of HA, however, resulted in a gradual loss of fibrous character. In addition, biomechanical properties were improved after HA deposition on PCL/PVA nanofibers as the value of Young's moduli of elasticity significantly increased. Clearly, thin-layer hydroxyapatite deposition on a nanofiber surface stimulated mesenchymal stem cell viability and their differentiation into osteoblasts. The optimal depth of HA was 800 nm. Pulsed laser deposition was proved as a suitable method for hydroxyapatite (HA) coating of coaxial poly-epsilon-aprolactone/polyvinylalcohol (PCL/PVA) nanofibers. The fibrous morphology of PCL/PVA nanofibers was preserved, if the nanofiber scaffold was coated with thin layers of HA (200nm and 400 nm). Increasing thickness of HA, however, resulted in a gradual loss of fibrous character. In addition, biomechanical properties were improved after HA deposition on PCL/PVA nanofibers as the value of Young's moduli of elasticity significantly increased. Clearly, thin-layer hydroxyapatite deposition on a nanofiber surface stimulated mesenchymal stem cell viability and their differentiation into osteoblasts. The optimal depth of HA was 800 nm. (en)
Title	Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts (en)
skos:prefLabel	Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts (en)
skos:notation	RIV/49777513:23520/12:43915509!RIV13-GA0-23520___
http://linked.open...avai/predkladatel	Fakulta aplikovaných věd
http://linked.open...avai/riv/aktivita	I P S V Z
http://linked.open...avai/riv/aktivity	I, P(2B06130), P(GA202/09/1151), P(GAP304/10/1307), P(GP106/09/P226), P(IAA500390702), P(ME10145), S, V, Z(AV0Z50390512), Z(AV0Z50390703)
http://linked.open...iv/cisloPeriodika	ID 428503
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kochová, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Západočeská univerzita v Plzni / Fakulta aplikovaných věd
http://linked.open...dnocenehoVysledku	174354
http://linked.open...ai/riv/idVysledku	RIV/49777513:23520/12:43915509
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hydroxyapatit, poly-epsilon-aprolactone/polyvinylalcohol, scaffold, mechanické vlastnosti, mesenchymální kmenové buňky (en)
http://linked.open.../riv/klicoveSlovo	hydroxyapatit mesenchymální kmenové buňky poly-epsilon-aprolactone/polyvinylalcohol scaffold mechanické vlastnosti
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[924EB3DE59E4]
http://linked.open...i/riv/nazevZdroje	Journal of Biomedicine and Biotechnology
http://linked.open...in/vavai/riv/obor	JJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Modification of nanofibers materials by plasma technologies for biomedical applications Synthesis of new biomaterials and preparation of stem cell derived cells, and their aplications in for the treatment of diseases affecting human tissues derived from mesoderm: cartilage, bone, ligament and meniscus. Focused tandem shock waves and their potential application in cancer treatment and controlled drug delivery Smart nanofiber/liposme composite scaffold for bone regeneration Development of software with graphical user interface for evaluation of mechanical measurements performed on soft biological tissues Scaffolds from liposome nanofibers for tissue engineering
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	2012
http://linked.open...iv/tvurceVysledku	Jelínek, Miroslav Kochová, Petra Kocourek, Tomáš Lukáš, David Vysloužilová, Lucie Amler, Evžen Prosecká, Eva Rampichová, Michala Buzgo, Matej Tvrdík, Daniel
http://linked.open...ain/vavai/riv/wos	000301378600001
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie New biotechnologies, nanomaterials and stem cells for use in regenerative medicine
issn	1110-7243
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1155/2012/428503
http://localhost/t...ganizacniJednotka	23520
is http://linked.open...avai/riv/vysledek of	Thin-Layer Hydroxyapatite Deposition on a Nanofiber Surface Stimulates Mesenchymal Stem Cell Proliferation and Their Differentiation into Osteoblasts

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