About: New derivatives of 5-azacytosine nucleosides like demethylating therapeutics: identification of clinical candidates and efficiency biomarkers.

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About: New derivatives of 5-azacytosine nucleosides like demethylating therapeutics: identification of clinical candidates and efficiency biomarkers. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=FR-TI4/625
Description	The project is focused to the development of new hypomethylating agents based on polymer conjugates of 5-azacytosine nucleosides and their 5,6-dihydro congeners, which will increase plasma half-life of the drug. This will not only pronounce therapeutical effect and increase survival time of the patients, but also allow application by standard quick infusion in a single dose instead of continuous several-day infusion. Costs for the therapy will be significantly reduced in this way also by removing the necessity of hospitalisation. (en) Projekt je zaměřen na vývoj nových hypometylačních agents na bázi polymerních konjugátů 5-azacytosinových nukleosidů a jejich 5,6-dihydroderivátů, které postupným uvolňováním prodlouží sérový poločas léčiva, a tím jednak zefektivní jeho působení a prodlouží přežití pacientů, jednak umožní jednorázové podání místo postupné dlouhodobé infúze. To podstatně sníží náklady na léčbu mimo jiné i odstraněním nutnosti hospitalizace a možností podat léčivo ambulantně.
Title	New derivatives of 5-azacytosine nucleosides like demethylating therapeutics: identification of clinical candidates and efficiency biomarkers. (en) Nové deriváty 5-azacytosinových nukleosidů jako demetylační léčiva: identifikace klinických kandidátů a biomarkerů účinnosti.
skos:notation	FR-TI4/625
http://linked.open...avai/cep/aktivita	TIP
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/FR-TI4%2F625/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/FR-TI4%2F625/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-02-09 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	101110728
http://linked.open...ai/cep/hlavniObor	FD - Onkologie a hematologie
http://linked.open...vai/cep/kategorie	AP - Aplikovaný výzkum
http://linked.open.../cep/klicovaSlova	epigenetics; hypomethylation; gene restoration; polymer conjugate; HPMA copolymer; controlled release; 5-azacytidine; decitabine; 5; 6-dihydro-5-azacytidine (en)
http://linked.open...ep/partnetrHlavni	Lékařská fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	3 (xsd:int)
http://linked.open.../pocetVysledkuRIV	11 (xsd:int)
http://linked.open...enychVysledkuVRIV	11 (xsd:int)
http://linked.open...lneniVMinulemRoce	2014-04-16 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/FR-TI4%2F625
http://linked.open...iciPoslednihoRoku	2015
http://linked.open...atUdajeProjZameru	2015
http://linked.open.../vavai/cep/soutez	SMPO2012/01
http://linked.open...usZobrazovaneFaze	DRRVK
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2015-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CC - Organická chemie
http://linked.open...ep/zahajeniReseni	2012-01-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBBK
http://linked.open.../cep/klicoveSlovo	epigenetics 5 5-azacytidine HPMA copolymer controlled release decitabine gene restoration hypomethylation polymer conjugate
is http://linked.open...vavai/riv/projekt of	Multistage-targeted pH-responsive polymer conjugate of Auger electron emitter: Optimized design and in vivo activity 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives Self-association of bee propolis: Effects on pharmaceutical applications Silver-coated monolithic columns for separation in radiopharmaceutical applications Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems Thermoresponsive polymer system based on poly(N-vinylcaprolactam) intended for local radiotherapy applications Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates Evaluation of Novel Acyclic Nucleoside Phosphonates against Human and Animal Gammaherpesviruses Revealed an Altered Metabolism of Cyclic Prodrugs upon Epstein-Barr Virus Reactivation in P3HR-1 Cells Study of complex thermosensitive amphiphilic polyoxazolines and their interaction with ionic surfactants. Are hydrophobic, thermosensitive, and hydrophilic moieties equally important? Chelating polymeric beads as potential therapeutics for Wilson’s disease N-4-Acyl derivatives as lipophilic prodrugs of cidofovir and its 5-azacytosine analogue, (S)-HPMP-5-azaC: Chemistry and antiviral activity
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