About: Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hydrazone conjugates of polymers with doxorubicin represent a very promising tool for cancer chemotherapy. However, these conjugates are very difficult to radiolabel with iodine radionuclides, which possess otherwise very advantageous nuclear properties to, e.g., follow biodistribution. In this study, we developed a robust protocol for the high-yield radioiodination of hydrazone-type drug delivery systems with doxorubicin. In particular, it is crucial that the polymer radioiodination step be performed before the deprotection of the hydrazide and doxorubicin binding. Hydrazone conjugates of polymers with doxorubicin represent a very promising tool for cancer chemotherapy. However, these conjugates are very difficult to radiolabel with iodine radionuclides, which possess otherwise very advantageous nuclear properties to, e.g., follow biodistribution. In this study, we developed a robust protocol for the high-yield radioiodination of hydrazone-type drug delivery systems with doxorubicin. In particular, it is crucial that the polymer radioiodination step be performed before the deprotection of the hydrazide and doxorubicin binding. (en)
Title	Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems (en)
skos:prefLabel	Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems Optimized protocol for the radioiodination of hydrazone-type polymer drug delivery systems (en)
skos:notation	RIV/61389013:_____/15:00439486!RIV15-GA0-61389013
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(FR-TI4/625), P(GAP304/12/0950), P(LH14079)
http://linked.open...iv/cisloPeriodika	January
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Hrubý, Martin Kučka, Jan Sedláček, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	335
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/15:00439486
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	doxorubicin; hydrazone; polymer conjugate (en)
http://linked.open.../riv/klicoveSlovo	polymer conjugate doxorubicin hydrazone
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F8F880B4045F]
http://linked.open...i/riv/nazevZdroje	Applied Radiation and Isotopes
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New derivatives of 5-azacytosine nucleosides like demethylating therapeutics: identification of clinical candidates and efficiency biomarkers. Chelating polymers as therapeuticals for Wilson´s disease Thermoresponsive polymer catalytic depots: in situ shaped reactors intended for biomedical purposes
http://linked.open...UplatneniVysledku	2015
http://linked.open...v/svazekPeriodika	95
http://linked.open...iv/tvurceVysledku	Hrubý, Martin Kučka, Jan Sedláček, Ondřej
http://linked.open...ain/vavai/riv/wos	000347585200021
issn	0969-8043
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.apradiso.2014.10.016

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