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  • The review summarizes the basic milestones of research of 5-azacytosine nucleosides, and their mechanism of action as inhibitors of DNA methylations. Compounds decitabine and 5-azacytidine became clinically used drugs. The second part of the review is paid to 5-azacytosine acyclic nucleoside analogues and phosphonomethyl derivatives as anti-DNA virus agents.
  • The review summarizes the basic milestones of research of 5-azacytosine nucleosides, and their mechanism of action as inhibitors of DNA methylations. Compounds decitabine and 5-azacytidine became clinically used drugs. The second part of the review is paid to 5-azacytosine acyclic nucleoside analogues and phosphonomethyl derivatives as anti-DNA virus agents. (en)
Title
  • 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives
  • 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives (en)
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  • 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives
  • 5-Azacytosine compounds in medicinal chemistry: current stage and future perspectives (en)
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  • RIV/61388963:_____/12:00377427!RIV13-AV0-61388963
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  • I, P(FR-TI4/625)
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  • 8
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  • 183529
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  • RIV/61388963:_____/12:00377427
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  • 5-azacytidine; 2´-deoxy-5-azacytidine; hypomethylation; DAC; epigenetics; DNA methylation; acyclic nucleoside phosphonates; 5-azacytosine; HPMP-5-azacytosine; prodrugs (en)
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  • GB - Spojené království Velké Británie a Severního Irska
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  • [702B4E34ABDA]
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  • Future Medicinal Chemistry
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  • 4
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  • Krečmerová, Marcela
  • Otmar, Miroslav
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  • 000304512000011
issn
  • 1756-8919
number of pages
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  • 10.4155/FMC.12.36
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