About: Brivanib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Brivanib
rdfs:subClassOf	Tyrosine Kinase Inhibitor nodeID://b648990 nodeID://b648991 nodeID://b648992 nodeID://b648993 nodeID://b648994
Has_Target	Vascular Endothelial Growth Factor Receptor-2
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Brivanib
UMLS_CUI	C1700095
CAS_Registry	649735-46-6
FDA_UNII_Code	DDU33B674I
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of cancer. Brivanib may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor 2 inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	539377
PDQ_Closed_Trial_Search_ID	539377
Chemical_Formula	C19H19FN4O3
Legacy_Concept_Name	BMS-540215
FULL_SYN	(R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5- methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan- 2-olSNNCI VEGFR2 Inhibitor BMS-540215SYNCI BRIVANIBPTFDADDU33B674I brivanibPTNCI-GLOSSCDR0000601196 BrivanibPTNCI BMS-540215CNNCI
DEFINITION	A pyrrolotriazine-based compound and an inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antineoplastic activity. BMS-540215 specifically targets and binds strongly to human VEGFR-2, a tyrosine kinase receptor and pro-angiogenic growth factor expressed almost exclusively on vascular endothelial cells. Blockade of VEGFR-2 by this agent may lead to an inhibition of VEGF-stimulated endothelial cell migration and proliferation, thereby inhibiting tumor angiogenesis.NCI
code	C67040
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0497578

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