About: CDK Inhibitor P276-00     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • CDK Inhibitor P276-00
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • CDK Inhibitor P276-00
UMLS_CUI
  • C1832023
PDQ_Open_Trial_Search_ID
  • 529362
PDQ_Closed_Trial_Search_ID
  • 529362
Legacy_Concept_Name
  • P276
FULL_SYN
  • P276CNNCI
  • Cyclin Dependent Kinase Inhibitor P276SYNCI
  • P276-00CNNCI
  • CDK Inhibitor P276-00PTNCI
DEFINITION
  • A flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.NCI
code
  • C64762
http://linked.open...y/mesh/hasConcept
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