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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • SB-743921
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • SB-743921
UMLS_CUI
  • C1709979
PDQ_Open_Trial_Search_ID
  • 456262
PDQ_Closed_Trial_Search_ID
  • 456262
Legacy_Concept_Name
  • SB-743921
FULL_SYN
  • SB-743921PTNCI
DEFINITION
  • A synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis.NCI
code
  • C52199
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