About: Mitotic Kinesin Modulator

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Attributes	Values
rdf:type	Class
rdfs:label	Mitotic Kinesin Modulator
rdfs:subClassOf	Antimitotic Agent
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Mitotic Kinesin Modulator
UMLS_CUI	C1881871
Legacy_Concept_Name	Mitotic_Kinesin_Modulator
FULL_SYN	Mitotic Kinesin ModulatorPTNCI
DEFINITION	A class of compounds that modulate the activity of mitotic kinesins. Mitotic kinesins or microtubule-associated proteins (MAPs) are ATP-powered proteins that convert energy into a mechanical force along the microtubule structure following the hydrolysis of ATP, which occurs during microtubule polymerization. Mitotic kinesins play an essential role in regulating the formation of the mitotic spindle as well as regulating their function. Agents that modulate the activity of kinesins, specifically those that produce inhibitory effects, interfere with mitotic spindle assembly, organization and eventually, chromosome alignment and segregation, thereby inducing mitotic arrest.NCI
code	C67440
is rdfs:subClassOf of	Tritylcysteine MK0731 SB-743921 KSP Inhibitor ARRY-520 Ispinesib Mesylate Ispinesib KSP Inhibitor AZD4877 Eg5 Kinesin-Related Motor Protein Inhibitor ARQ 621 Litronesib Eg5 Kinesin-Related Motor Protein Inhibitor 4SC-205

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