About: Zosuquidar Trihydrochloride

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About: Zosuquidar Trihydrochloride Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Zosuquidar Trihydrochloride
rdfs:subClassOf	Multidrug Resistance Modulator
Has_Free_Acid_Or_Base_Form	Zosuquidar
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Zosuquidar Trihydrochloride
NSC_Code	725086
UMLS_CUI	C0528372
CAS_Registry	167465-36-3
In_Clinical_Trial_For	Acute Myeloid Leukemia and Refractory Anemia
FDA_UNII_Code	813AGY3126
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of cancer. Zosuquidar trihydrochloride may help kill cancer cells that are resistant to anticancer drugs.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43659
PDQ_Closed_Trial_Search_ID	43659
Chemical_Formula	C32H31F2N3O2.3ClH
Legacy_Concept_Name	Zosuquidar_Trihydrochloride
FULL_SYN	Zosuquidar TrihydrochloridePTNCI zosuquidar trihydrochloridePTNCI-GLOSSCDR0000257971 LY335979PTNCI-GLOSSCDR0000046762 (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, TrihydrochlorideSNNCI LY335979CNNCI ZOSUQUIDAR TRIHYDROCHLORIDEPTFDA813AGY3126
DEFINITION	A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. (NCI04)NCI
code	C2225
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0250672
is someValuesFrom of	nodeID://b663995 nodeID://b686235 nodeID://b723023
is Has_Salt_Form of	Zosuquidar

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