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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zosuquidar
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Zosuquidar
UMLS_CUI
  • C2700337
CAS_Registry
  • 167354-41-8
FDA_UNII_Code
  • AB5K82X98Y
Contributing_Source
  • FDA
Chemical_Formula
  • C32H31F2N3O2
Legacy_Concept_Name
  • Zosuquidar
FULL_SYN
  • ZosuquidarPTNCI
  • (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanolSNNCI
  • ZOSUQUIDARPTFDAAB5K82X98Y
DEFINITION
  • A difluorocyclopropyl quinoline. Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.NCI
code
  • C76198
is Has_Free_Acid_Or_Base_Form of
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