About: NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

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About: NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In vivo depletion of CD8+ cells resulted in complete elimination of protective effects after immunization with TC-1 cells (MHC class I+) against the TC-1 tumour challenge. After immunization with TC-1/A9 or MK16 tumour cells (MHC class I-deficient) a remarkable dependence on the presence of NK1.1+ cells was observed, Cytotoxic activity induced by TC-1 cell immunization was abrogated in CD8+ cell-depleted mice and the mice showed similar percentage of IFNgamma-producing cells in CD8+, CD4+ and NK1.1+ subpopulations.. After MK16 or TC-1/A9 cell immunization, NK1.1+ displayed significant reduction of cytotoxicity. The highest proportion of IFNgamma-producing cells was concentrated into the NK1.1+ cells.. In vivo depletion of CD8+ cells resulted in complete elimination of protective effects after immunization with TC-1 cells (MHC class I+) against the TC-1 tumour challenge. After immunization with TC-1/A9 or MK16 tumour cells (MHC class I-deficient) a remarkable dependence on the presence of NK1.1+ cells was observed, Cytotoxic activity induced by TC-1 cell immunization was abrogated in CD8+ cell-depleted mice and the mice showed similar percentage of IFNgamma-producing cells in CD8+, CD4+ and NK1.1+ subpopulations.. After MK16 or TC-1/A9 cell immunization, NK1.1+ displayed significant reduction of cytotoxicity. The highest proportion of IFNgamma-producing cells was concentrated into the NK1.1+ cells.. (en)
Title	NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours (en)
skos:prefLabel	NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours (en)
skos:notation	RIV/68378050:_____/11:00355110!RIV11-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA500520807), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Reiniš, Milan Šímová, Jana Bieblová, Jana Bubeník, Jan Indrová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	216094
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00355110
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MHC class I-deficient tumours; CD8+, CD4+, NK1.1+cell subpopulations; interferon gamma (en)
http://linked.open.../riv/klicoveSlovo	CD4+ CD8+ MHC class I-deficient tumours NK1.1+cell subpopulations interferon gamma
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[AD07285D49A3]
http://linked.open...i/riv/nazevZdroje	Oncology Reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms of protective immunity against tumours with different expression of immunodulatory molecules
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Reiniš, Milan Bieblová, Jana Bubeník, Jan Indrová, Marie Šímová, Jana
http://linked.open...ain/vavai/riv/wos	000286303800038
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1021-335X
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours NK1.1+ cells are important for the development of protective immunity against MHC I-deficient, HPV16-associated tumours

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