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Description
| - The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P)H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1.
- The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P)H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1. (en)
- Krystalová struktura flavodoxinu podobného proteinu WrbA s navázaným FMN odhaluje blízkou struturní příbuznost s eukariotními NAD(P)H zavislými chinon oxidoreduktasami, Nqo1. Porovnání krystalových struktur WrbA, Flavodoxinu a Nqo1 ukazuje jak je stočená otevřená struktura beta skládaného listu uspořádána tak, aby vznikl multimer, který rozšiřuje katalitickou funkci z jednoelektronového přenosu na dvouelektronový. Strukturní analýza naznačuje možné nové fyziologické funkce proteinů WrbA a Nqo1. (cs)
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Title
| - WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases
- Protein WrbA tvoří most mezi bakterialními Flavodoxiny a eukariotními NAD(P)H zavislými chinon oxidoreduktasami (cs)
- WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases (en)
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skos:prefLabel
| - WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases
- Protein WrbA tvoří most mezi bakterialními Flavodoxiny a eukariotními NAD(P)H zavislými chinon oxidoreduktasami (cs)
- WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases (en)
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skos:notation
| - RIV/68378050:_____/07:00097983!RIV08-AV0-68378050
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - Z(AV0Z50520514), Z(AV0Z60870520)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00097983
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - WrbA; crystal structure; Nqo1; oxidoreductases (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brynda, Jiří
- Ettrich, Rüdiger
- Kutá-Smatanová, Ivana
- Carey, J.
- Wolfová, Julie
- Grandori, R.
- Gustavsson, T.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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