About: Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Některé acyklické nukleosidfosfonáty aktivují u lidských mononukleárních buněk periferní krve in vitro sekreci chemokinů MIP-1 alfa a RANTES. Vliv na sekreci interleukinu IL-16 a interferonu IFN-gama nebyl pozorován. Acyklické nukleosidfosfonáty tak představují novou generaci antivirotik s vlastnostmi jak antimetabolickými, tak i s vlastnostmi imunostimulačními, které mohou být terapeuticky zajímavé z hlediska léčby infekce HIV. (cs) Some acyclic nucleoside phosphonates substantially enhance in vitro secretion of chemokines such as macrophage inflammatory protein-1alfa (MIP-alfa) and regulated on activation of normal T cell expressed and secreted (RANTES) by human peripheral blood mononuclear cells. Secretion of interleukin-16 (IL-16) and interferon-gama (IFN-gama) remained uninfluenced. It may be suggested that acyclic nucleoside phosphonates represent a new generation of antivirotics with combined antimetabolic and therapeutically prospective immunostimulatory properties. These effects may be therapeutically important in therapy of HIV infection. Some acyclic nucleoside phosphonates substantially enhance in vitro secretion of chemokines such as macrophage inflammatory protein-1alfa (MIP-alfa) and regulated on activation of normal T cell expressed and secreted (RANTES) by human peripheral blood mononuclear cells. Secretion of interleukin-16 (IL-16) and interferon-gama (IFN-gama) remained uninfluenced. It may be suggested that acyclic nucleoside phosphonates represent a new generation of antivirotics with combined antimetabolic and therapeutically prospective immunostimulatory properties. These effects may be therapeutically important in therapy of HIV infection. (en)
Title	Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates (en) Sekrece antiretrovirálních chemokinů lidskými buňkami po stimulaci acyklickými fosfonáty nukleosidů (cs)
skos:prefLabel	Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates (en) Sekrece antiretrovirálních chemokinů lidskými buňkami po stimulaci acyklickými fosfonáty nukleosidů (cs)
skos:notation	RIV/68378041:_____/07:00091224!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany	77;84
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0508), Z(AV0Z40550506), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Zídek, Zdeněk Kmoníčková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	449153
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/07:00091224
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Acyclic nucleoside phosphonate; Chemokine; Cytokine (en)
http://linked.open.../riv/klicoveSlovo	Acyclic nucleoside phosphonate Cytokine Chemokine
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[2A1A6F208AFE]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmacology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	New Antivirals and Antineoplastics
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	574
http://linked.open...iv/tvurceVysledku	Holý, Antonín Zídek, Zdeněk Kmoníčková, Eva
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0014-2999
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates

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