About: Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464.

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About: Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The novel antitumor platinum drug BBR3464 forms on DNA intrastrand adducts which change its local conformation in a way that they do not induce a stable curvature. These intrastrand adducts are not recognized by HMG domain proteins, but they are effectively removed from DNA by nucleotide excision repair. It has been concluded that the processing of these adducts in tumor cells may not be relevant to the antitumor effect of BBR3464 The novel antitumor platinum drug BBR3464 forms on DNA intrastrand adducts which change its local conformation in a way that they do not induce a stable curvature. These intrastrand adducts are not recognized by HMG domain proteins, but they are effectively removed from DNA by nucleotide excision repair. It has been concluded that the processing of these adducts in tumor cells may not be relevant to the antitumor effect of BBR3464 (en)
Title	Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464. Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464. (en)
skos:prefLabel	Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464. Conformation, Recognition by High Mobility Group Domain Proteins, and Nucleotide Excision Repair of DNA Intrastrand Cross-links of Novel Antitumor Trinuclear Platinum Complex BBR3464. (en)
skos:notation	RIV/68081707:_____/01:17013054!RIV/2003/AV0/A17003/N
http://linked.open.../vavai/riv/strany	22191;22199
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/99/0695), P(IAA5004101), P(NL6058), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	25
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Zehnulová, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	676256
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/01:17013054
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cisplatin-modified DNA; drug cis-diamminedichloroplatinum(II), (en)
http://linked.open.../riv/klicoveSlovo	cisplatin-modified DNA drug cis-diamminedichloroplatinum(II)
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[92238F9501F0]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Affection of DNA conformation by metal-based anticancer drugs. Relations to the development of new cytostatics Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs Recognition and repair of DNA damage by antitumor platinum drugs.Relations to the development of new anticancer drugs.
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	276
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Farrell, N. Zehnulová, Jana
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0021-9258
number of pages	9 (xsd:int)

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