About: Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies

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About: Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Neurodegenerative diseases are devastating disorders and the demands on their treatment are set to rise in connection with higher disease incidence. Knowledge of the spatiotemporal profile of cellular protein expression during neural differentiation and definition of a set of markers highly specific for targeted neural populations is a key challenge. Intracellular proteins may be utilized as a readout for follow-up transplantation and cell surface proteins may facilitate isolation of the cell subpopulations, while secreted proteins could help unravel intercellular communication and immunomodulation. This review summarizes the potential of proteomics in revealing molecular mechanisms underlying neural differentiation of stem cells and presents novel candidate proteins of neural subpopulations, where understanding of their functionality may accelerate transition to cell replacement therapies. Neurodegenerative diseases are devastating disorders and the demands on their treatment are set to rise in connection with higher disease incidence. Knowledge of the spatiotemporal profile of cellular protein expression during neural differentiation and definition of a set of markers highly specific for targeted neural populations is a key challenge. Intracellular proteins may be utilized as a readout for follow-up transplantation and cell surface proteins may facilitate isolation of the cell subpopulations, while secreted proteins could help unravel intercellular communication and immunomodulation. This review summarizes the potential of proteomics in revealing molecular mechanisms underlying neural differentiation of stem cells and presents novel candidate proteins of neural subpopulations, where understanding of their functionality may accelerate transition to cell replacement therapies. (en)
Title	Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies (en)
skos:prefLabel	Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies Proteome-wide analysis of neural stem cell differentiation to facilitate transition to cell replacement therapies (en)
skos:notation	RIV/67985904:_____/15:00441648!RIV15-TA0-67985904
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0124), P(TA01011466)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Žižková, Martina Kotrčová, Eva Kovářová, Hana Hrabáková, Rita Jarkovská, Karla Mairychová, Kateřina Tylečková, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	370
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/15:00441648
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cell therapy; immunomodulation; neural stem cell differentiation; neural subpopulation; neurodegenerative disease (en)
http://linked.open.../riv/klicoveSlovo	immunomodulation cell therapy neural stem cell differentiation neural subpopulation neurodegenerative disease
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[AE0129BAAD86]
http://linked.open...i/riv/nazevZdroje	Expert Review of Proteomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	ExAM Experimental Animal Models Biomedical model of miniature pigs for testing of new medicaments and for new treatments of traumatic spinal cord injury and neurodegenerative diseases
http://linked.open...UplatneniVysledku	2015
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Gadher, S. J. Jarkovská, Karla Kovářová, Hana Mairychová, Kateřina Tylečková, Jiřina Marsala, M. Kotrčová, Eva Suchá, Rita Žižková, Martina
http://linked.open...ain/vavai/riv/wos	000348763900009
issn	1478-9450
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1586/14789450.2015.977381

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