About: Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites.

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About: Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	With respect to the mechanism of chaperone-like activity, we examined the behaviour of haptoglobin under heat shock conditions. Secondary structure changes during heat treatment were followed by circular dichroism, Raman spectroscopy and infrared spectroscopy. A model of the haptoglobin tetramer, based on its sequence homology with serine proteases and the CCP modules, has been proposed. Sequence regions responsible for the chaperone-like activity were not fully identical with the region that took part in formation of the hemoglobin-haptoglobin complex. We can postulate presence of at least two different chaperone-binding sites on each haptoglobin heavy chain. With respect to the mechanism of chaperone-like activity, we examined the behaviour of haptoglobin under heat shock conditions. Secondary structure changes during heat treatment were followed by circular dichroism, Raman spectroscopy and infrared spectroscopy. A model of the haptoglobin tetramer, based on its sequence homology with serine proteases and the CCP modules, has been proposed. Sequence regions responsible for the chaperone-like activity were not fully identical with the region that took part in formation of the hemoglobin-haptoglobin complex. We can postulate presence of at least two different chaperone-binding sites on each haptoglobin heavy chain. (en)
Title	Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites. Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites. (en)
skos:prefLabel	Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites. Study of chaperone-like activity of human haptoglobin: conformational changes under heat shock conditions and localization of interaction sites. (en)
skos:notation	RIV/67985823:_____/02:20030020!RIV/2004/AV0/A20004/N
http://linked.open.../vavai/riv/strany	1667;1676
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5011922), Z(MSM 113100001)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Hofbauerová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	665699
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/02:20030020
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	chaperone; haptoglobin; molecular modeling (en)
http://linked.open.../riv/klicoveSlovo	molecular modeling chaperone haptoglobin
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[839934B23E81]
http://linked.open...i/riv/nazevZdroje	Biological Chemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	383
http://linked.open...iv/tvurceVysledku	Hofbauerová, Kateřina Baumruk, V. Kopecký jr., V. Ettrich, R. Pavlíček, Z. Brandt, W.
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100001
issn	1431-6730
number of pages	10 (xsd:int)

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