About: Structure-Function Relationships and Engineering of Haloalkane Dehalogenases

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Structure-Function Relationships and Engineering of Haloalkane Dehalogenases Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The structure–function relationships for haloalkane dehalogenases, representing one of the best characterized families of enzymes involved in degradation of halogenated compounds is described. A substantial amount of mechanistic and structural information is currently available on haloalkane dehalogenases, providing good theoretical framework for their modification by protein engineering. Examples of constructed mutants include variants with modified: (1) activity, (2) thermostability, (3) substrate specificity and (4) enantioselectivity. Some variants carried mutations in the tunnels, connecting the buried active site with surrounding solvent, rather in the active site itself. Mutagenesis in the residues lining the protein tunnels represents a new paradigm in protein engineering. The structure–function relationships for haloalkane dehalogenases, representing one of the best characterized families of enzymes involved in degradation of halogenated compounds is described. A substantial amount of mechanistic and structural information is currently available on haloalkane dehalogenases, providing good theoretical framework for their modification by protein engineering. Examples of constructed mutants include variants with modified: (1) activity, (2) thermostability, (3) substrate specificity and (4) enantioselectivity. Some variants carried mutations in the tunnels, connecting the buried active site with surrounding solvent, rather in the active site itself. Mutagenesis in the residues lining the protein tunnels represents a new paradigm in protein engineering. (en)
Title	Structure-Function Relationships and Engineering of Haloalkane Dehalogenases Structure-Function Relationships and Engineering of Haloalkane Dehalogenases (en)
skos:prefLabel	Structure-Function Relationships and Engineering of Haloalkane Dehalogenases Structure-Function Relationships and Engineering of Haloalkane Dehalogenases (en)
skos:notation	RIV/00216224:14310/08:00026663!RIV11-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LC06010), Z(MSM0021622412)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Chovancová, Eva Pavlová, Martina Damborský, Jiří Brezovský, Jan Chaloupková, Radka
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	397860
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/08:00026663
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	QSAR; haloalkan dehalogenases (en)
http://linked.open.../riv/klicoveSlovo	haloalkan dehalogenases QSAR
http://linked.open...ontrolniKodProRIV	[F3D0C69C61B0]
http://linked.open...i/riv/mistoVydani	Heidelberg
http://linked.open...vEdiceCisloSvazku	Handbooks, 1
http://linked.open...i/riv/nazevZdroje	Handbook of Hydrocarbon and Lipid Microbiology
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...v/pocetStranKnihy	4480 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Biocatalysis and Biotransformation
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Brezovský, Jan Chaloupková, Radka Chovancová, Eva Damborský, Jiří Pavlová, Martina
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
number of pages	18 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Springer-Verlag
https://schema.org/isbn	978-3-540-77584-3
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	Structure-Function Relationships and Engineering of Haloalkane Dehalogenases Structure-Function Relationships and Engineering of Haloalkane Dehalogenases Structure-Function Relationships and Engineering of Haloalkane Dehalogenases

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 106 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software