About: Nestin expression throughout multistep pathogenesis of multiple myeloma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The stem cell marker nestin (NES) is found in dividing cells of developing and regenerating tissues. Upon terminal differentiation, NES expression is diminished but may be re-expressed following injury or in cancer. Surprisingly, we recently confirmed NES as a tumour-specific marker for mature CD138(+)38(+) plasma cells (PC) in multiple myeloma (MM). The present study analysed NES expression throughout the spectrum of MM developmental stages, starting with individuals with no haematological malignancy, through monoclonal gammopathy of undetermined significance (MGUS) and MM to plasma cell leukaemia (PCL) and MM cell lines. NES was analysed in bone marrow PC of 163 MM, four PCL and nine MGUS patients, 10 individuals with no haematological malignancy and 6 myeloma cell lines (OPM-2, RPMI-8226, MOLP-8, U-266, EJM, NCI-H929) by flow cytometry and/or real-time polymerase chain reaction or immunochemistry. We observed a tendency of increased NES expression in parallel with disease progression. The stem cell marker nestin (NES) is found in dividing cells of developing and regenerating tissues. Upon terminal differentiation, NES expression is diminished but may be re-expressed following injury or in cancer. Surprisingly, we recently confirmed NES as a tumour-specific marker for mature CD138(+)38(+) plasma cells (PC) in multiple myeloma (MM). The present study analysed NES expression throughout the spectrum of MM developmental stages, starting with individuals with no haematological malignancy, through monoclonal gammopathy of undetermined significance (MGUS) and MM to plasma cell leukaemia (PCL) and MM cell lines. NES was analysed in bone marrow PC of 163 MM, four PCL and nine MGUS patients, 10 individuals with no haematological malignancy and 6 myeloma cell lines (OPM-2, RPMI-8226, MOLP-8, U-266, EJM, NCI-H929) by flow cytometry and/or real-time polymerase chain reaction or immunochemistry. We observed a tendency of increased NES expression in parallel with disease progression. (en)
Title	Nestin expression throughout multistep pathogenesis of multiple myeloma Nestin expression throughout multistep pathogenesis of multiple myeloma (en)
skos:prefLabel	Nestin expression throughout multistep pathogenesis of multiple myeloma Nestin expression throughout multistep pathogenesis of multiple myeloma (en)
skos:notation	RIV/00216224:14110/14:00073562!RIV15-MSM-14110___
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(GAP304/10/1395), P(NT11154), P(NT13190), Z(MSM0021622434)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Šváchová, Hana Kryukov, Fedor Ševčíková, Sabina Říhová, Lucie Hájek, Roman Němec, Pavel Grešliková, Henrieta Kubiczková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	32185
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/14:00073562
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nestin; multiple myeloma; monoclonal gammopathy; stem cells; flow cytometry (en)
http://linked.open.../riv/klicoveSlovo	stem cells flow cytometry multiple myeloma nestin monoclonal gammopathy
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B14C7CDD60CC]
http://linked.open...i/riv/nazevZdroje	British journal of haematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	164
http://linked.open...iv/tvurceVysledku	Hájek, Roman Kryukov, Fedor Říhová, Lucie Ševčíková, Sabina Šváchová, Hana Němec, Pavel Grešliková, Henrieta Kryukova, Elena Vladimirovna Kubiczková, Lenka
http://linked.open...ain/vavai/riv/wos	000331354700011
http://linked.open...n/vavai/riv/zamer	From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies
issn	0007-1048
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1111/bjh.12689
http://localhost/t...ganizacniJednotka	14110

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