About: Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://informahealthcare.com/doi/full/10.1517/17425255.2014.878703
Description	The aim of this paper is to summarize the molecular effects of GCs on CYP as well as the available clinical evidence on drug--drug interactions (DDIs) between GCs and other drugs in which GCs influence the metabolism of other edicines through modifying CYP activity. We used the factographic database DRUGDEX along with bibliographic searches. Expert opinion: Most of the literature reported CYP3A4 induction by GCs, but this was not proved in all research. As the onclusions on these DDIs are conflicting, there are several issues to be considered like the dosage of GCs, the length of GCs treatment and concomitant therapy, all of which can have an additive inducing effect. Further, in designing a DDI study, crossover studies are preferred. A literature search of the abovementioned information resources provided dissimilar results. The aim of this paper is to summarize the molecular effects of GCs on CYP as well as the available clinical evidence on drug--drug interactions (DDIs) between GCs and other drugs in which GCs influence the metabolism of other edicines through modifying CYP activity. We used the factographic database DRUGDEX along with bibliographic searches. Expert opinion: Most of the literature reported CYP3A4 induction by GCs, but this was not proved in all research. As the onclusions on these DDIs are conflicting, there are several issues to be considered like the dosage of GCs, the length of GCs treatment and concomitant therapy, all of which can have an additive inducing effect. Further, in designing a DDI study, crossover studies are preferred. A literature search of the abovementioned information resources provided dissimilar results. (en)
Title	Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction (en)
skos:prefLabel	Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction (en)
skos:notation	RIV/00216208:11160/14:10281729!RIV15-MSM-11160___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(EE2.3.20.0054), P(GBP303/12/G163)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pávek, Petr Vlček, Jiří Malý, Josef Matoulková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	9540
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/14:10281729
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glucocorticoid receptors; information systems; drug interactions; cytochrome P450 enzyme systém (en)
http://linked.open.../riv/klicoveSlovo	information systems drug interactions cytochrome P450 enzyme systém glucocorticoid receptors
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[E9B470D56E9C]
http://linked.open...i/riv/nazevZdroje	Expert Opinion on Drug Metabolism and Toxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of drug-dietary supplements interactions and nutrigenetics Developing and integration of R&D teams of HEPIN into international research of portal hypertension.
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Pávek, Petr Vlček, Jiří Malý, Josef Matoulková, Petra
http://linked.open...ain/vavai/riv/wos	000331834200009
issn	1742-5255
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1517/17425255.2014.878703
http://localhost/t...ganizacniJednotka	11160

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