About: Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects     Goto   Sponge   NotDistinct   Permalink

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  • Symptoms of human leishmaniasis range from subclinical to extensive systemic disease, but the basis of these variations is unknown. We analyzed the symptomatology of leishmaniasis in mice by monitoring skin lesions, hepatomegaly, splenomegaly and seven immunological parameters. We detected and mapped 17 Leishmania major response (Lmr) gene loci that control the symptoms of infection. Surprisingly, the individual Lmr loci control 13 different combinations of pathological and immunological symptoms. These findings extend the paradigm for the genetics of host response to infection to include numerous genes, each controlling a different set of organ-specific and systemic effects.
  • Symptoms of human leishmaniasis range from subclinical to extensive systemic disease, but the basis of these variations is unknown. We analyzed the symptomatology of leishmaniasis in mice by monitoring skin lesions, hepatomegaly, splenomegaly and seven immunological parameters. We detected and mapped 17 Leishmania major response (Lmr) gene loci that control the symptoms of infection. Surprisingly, the individual Lmr loci control 13 different combinations of pathological and immunological symptoms. These findings extend the paradigm for the genetics of host response to infection to include numerous genes, each controlling a different set of organ-specific and systemic effects. (en)
  • Projevy leishmaniosy u člověka jsou pozorovány v rozsahu od subklinických po projevy rozsáhlého systémového onemocnění. Příčiny těchto odlišností dosud nejsou známy. Analyzovali jsme symptomatologii leishmaniosy u myší tak, že jsme monitorovali vývoj lezí, hepatomegalii, splenomegalii a sedm imunologických parametrů. Objevili jsme 17 genových lokusů odpovědi na Leishmania major (Lmr), které kontrolují projevy infekce. Překvapivě jednotlivé Lmr lokusy kontrolovaly 13 různých kombinací patologických a imunologických symptomů. Tento nález rozšiřuje názor na odpověď hostitele na infekci. Naše práce ukazuje, že odpověď na infekci je řízena mnoha geny, z nichž každý kontroluje různé skupiny orgánově specifických a systémových efektů. (cs)
Title
  • Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects
  • Genetická vnímavost k leishmaniáze u myši: čtyři nové lokusy a funkční heterogenita genetických efektů (cs)
  • Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects (en)
skos:prefLabel
  • Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects
  • Genetická vnímavost k leishmaniáze u myši: čtyři nové lokusy a funkční heterogenita genetických efektů (cs)
  • Genetics of susceptibility to leshmaniasis in mice: four novel loci and functional heterogeneity of gene effects (en)
skos:notation
  • RIV/00216208:11120/06:00000506!RIV09-AV0-11120___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 476899
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11120/06:00000506
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • leishmaniasis; host response; gene effect (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [EE85341EDD2F]
http://linked.open...i/riv/nazevZdroje
  • Genes and Immunity
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Lipoldová, Marie
  • Havelková, H.
http://linked.open...ain/vavai/riv/wos
  • 000237100100005
http://linked.open...n/vavai/riv/zamer
issn
  • 1466-4879
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http://localhost/t...ganizacniJednotka
  • 11120
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