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| rdf:type
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| Description
| - PAHs with molecular weight 278 are mostly not covered by the monitoring programs. Although benzo[g]chrysene (BgChry) and dibenzo[a,h]anthracene have been for a long time studied as genotoxic, tumour-initiating compounds, little is known about their potential tumour-promoting effects. We investigated their impact on activation of receptor AhR, induction of xenobiotic-metabolizing enzymes, disruption of cell cycle control in confluent cell population and inhibition of gap junctional intercellular communication, using the rat liver epithelial cell line WB-F344 as a model of liver progenitor cells. The results suggest, that dibenzoanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high AhR-mediated activity. The disruption of cell cycle control might potentially contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures.
- PAHs with molecular weight 278 are mostly not covered by the monitoring programs. Although benzo[g]chrysene (BgChry) and dibenzo[a,h]anthracene have been for a long time studied as genotoxic, tumour-initiating compounds, little is known about their potential tumour-promoting effects. We investigated their impact on activation of receptor AhR, induction of xenobiotic-metabolizing enzymes, disruption of cell cycle control in confluent cell population and inhibition of gap junctional intercellular communication, using the rat liver epithelial cell line WB-F344 as a model of liver progenitor cells. The results suggest, that dibenzoanthracenes and benzochrysenes, with exception of BgChry, seem to act primarily through deregulation of cell proliferation in liver epithelial cells, which is related to their relatively high AhR-mediated activity. The disruption of cell cycle control might potentially contribute to their carcinogenic effects, as well as to carcinogenicity of complex environmental mixtures. (en)
- PAHs s molekulární hmotností 278 většinou nejsou zahrnuty v současných monitorovacích programech. Přestože benzo[g]chrysen (BgChry) a dibenzo[a,h]anthracen jsou dlouhou dobu studovány jako genotoxické, tumor-iniciační sloučeniny, je málo známo o možných tumor-promočních schopnostech této skupiny PAHs. Zabývali jsme se jejich vlivem na aktivaci receptoru AhR, indukci enzymů metabolizujících xenobiotika, narušení kontroly buněčného cyklu v konfluentní buněčné populaci a inhibici mezibuněčné populace za použití potkaních jaterních epiteliálních buněk WB-F344 jako modelu jaterních progenitorových buněk. Výsledky ukazují, že dibenzoanthraceny a benzochryseny s výjimkou BgChry pravděpodobně působí prostřednictvím deregulace buněčné proliferace v jaterních epiteliálních buňkách, což souvisí s jejich relativně vysokou aktivitou řízenou AhR. Narušení kontroly buněčného cyklu by mohlo přispívat k jejich karcinogenním účinkům, stejně jako ke karcinogenitě komplexních environmentálních směsí. (cs)
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| Title
| - Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells
- Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells (en)
- Dibenzoanthraceny a benzochryseny projevují jak genotoxické, tak negenotoxické účinky v potkaních jaterních 'stem-like' buňkách (cs)
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| skos:prefLabel
| - Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells
- Dibenzanthracenes and benzochrysenes elicit both genotoxic and nongenotoxic events in rat liver 'stem-like' cells (en)
- Dibenzoanthraceny a benzochryseny projevují jak genotoxické, tak negenotoxické účinky v potkaních jaterních 'stem-like' buňkách (cs)
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| skos:notation
| - RIV/00027162:_____/07:#0000281!RIV08-MZE-00027162
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(KJB6004407), Z(AV0Z50040507), Z(AV0Z50390512), Z(MZE0002716201)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/07:#0000281
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - aryl hydrocarbon receptor; genotoxicity; rat liver epithelial cells; benzochrysenes; dibenzoanthracenes; cell proliferation (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Vondráček, Jan
- Machala, Miroslav
- Topinka, J.
- Neča, Jiří
- Pěnčíková, Kateřina
- Marvanová, Soňa
- Kozubík, A.
- Švihálková, Lenka
- Sevastyanová, O.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| is http://linked.open...avai/riv/vysledek
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