About: Vincristine

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Vincristine Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vincristine
rdfs:subClassOf	Vinca-Domain Binding Agent Vinca Alkaloids nodeID://b722981 nodeID://b722982 nodeID://b722983
Has_Salt_Form	Vincristine Sulfate
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Vincristine
UMLS_CUI	C0042679
CAS_Registry	57-22-7
Accepted_Therapeutic_Use_For	Acute leukemia; Brain tumors; Chronic lymphocytic leukemia; Gestational trophoblastic neoplasms; Head and Neck squamous cell carcinoma; Kaposis sarcoma; Liver cancer; Lymphoma, Hodgkins, Non-Hodgkins; Malignant thymoma; Multiple myeloma; Osteogenic sarcoma; Ovarian cancer; Pheochromocytoma; Retinoblastoma; Rhabdomyosarcoma; Soft tissue sarcoma; Testicular cancer; Wilms tumor
In_Clinical_Trial_For	Myelodysplastic and Myeloproliferative diseases; Neuroblastoma; Osteosarcoma; Rhabdomyosarcoma; Soft Tissue sarcoma; Wilms' Tumor Adrenal Cortex Neoplasms; Brain tumors; Childhood Medulloblastoma; Ependymoma; Ewing's sarcoma; Leukemia; Lymphoma; Glioma(s); Medulloblastoma; Multiple Myeloma;
FDA_UNII_Code	5J49Q6B70F
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Vincristine is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.NCI-GLOSS
Chemical_Formula	C46H56N4O10
Legacy_Concept_Name	Vincristine
CHEBI_ID	CHEBI:28445
FULL_SYN	VincristinePTNCI VincrystineSYNCI LEUROCRISTINESYDTPNSC0067574 VincristineSYNCITCGA 22-OxovincaleukoblastineSNNCI vincristinePTNCI-GLOSSCDR0000045435 LeurocristineSYNCI VincristinePTDCP02166 VCRABNCI VINCRISTINEPTFDA5J49Q6B70F VINCRISTINESYDTPNSC0067574
DEFINITION	A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)NCI
code	C933
sameAs	VINCRISTINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0022676
is someValuesFrom of	nodeID://b642940 nodeID://b644820 nodeID://b645111 nodeID://b645113 nodeID://b645129 nodeID://b645600 nodeID://b646761 nodeID://b646774 nodeID://b646777 nodeID://b646785 nodeID://b646789 nodeID://b646799 nodeID://b646805 nodeID://b646815 nodeID://b646821 nodeID://b646825 nodeID://b646839 nodeID://b646845 nodeID://b646849 nodeID://b646868 nodeID://b646874 nodeID://b646888 nodeID://b646894 nodeID://b646905 nodeID://b646911 nodeID://b646915 nodeID://b646922 nodeID://b646924 nodeID://b646934 nodeID://b646935 nodeID://b646951 nodeID://b646956 nodeID://b646962 nodeID://b646970 nodeID://b646971 nodeID://b646977 nodeID://b646983 nodeID://b646996 nodeID://b647002 nodeID://b647016 nodeID://b647020 nodeID://b647029 nodeID://b647032 nodeID://b647039 nodeID://b647059 nodeID://b647064 nodeID://b647076 nodeID://b647085 nodeID://b647105 nodeID://b647116 nodeID://b647133 nodeID://b647137 nodeID://b647141 nodeID://b647146 nodeID://b647161 nodeID://b647162 nodeID://b647169 nodeID://b647175 nodeID://b647181 nodeID://b647185 nodeID://b647190

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 123 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software