About: Pegylated Liposomal Irinotecan     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pegylated Liposomal Irinotecan
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pegylated Liposomal Irinotecan
UMLS_CUI
  • C1831956
PDQ_Open_Trial_Search_ID
  • 506099
PDQ_Closed_Trial_Search_ID
  • 506099
Legacy_Concept_Name
  • Liposomal_Irinotecan
FULL_SYN
  • IHL-305CNNCI
  • Pegylated Liposomal IrinotecanPTNCI
DEFINITION
  • A formulation of polyethylene glycol (PEG)-modified liposomes encapsulating the semisynthetic derivative of camptothecin irinotecan, with antineoplastic activity. As a prodrug, irinotecan is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. In turn, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks. This results in an inhibition of DNA replication and an induction of apoptosis. Pegylated liposomal delivery of irinotecan improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of exposure while lowering systemic toxicity.NCI
code
  • C62789
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