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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • TTI-237
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • TTI-237
UMLS_CUI
  • C1831611
In_Clinical_Trial_For
  • Advanced Solid Tumors.
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 432958
PDQ_Closed_Trial_Search_ID
  • 432958
Legacy_Concept_Name
  • TTI-237
FULL_SYN
  • TTI-237PTNCI-GLOSSCDR0000438726
  • TTI 237SYNCI
  • TTI-237PTNCI
DEFINITION
  • A small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. TTI-237 stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death.NCI
code
  • C61566
http://linked.open...y/mesh/hasConcept
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