About: HLA-DR Antigen

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	HLA-DR Antigen
rdfs:subClassOf	Histocompatibility Antigens Class II nodeID://b678310 nodeID://b678311 nodeID://b678312 nodeID://b678313 nodeID://b678314 nodeID://b678315 nodeID://b678316 nodeID://b678317 nodeID://b678318
Semantic_Type	Amino Acid, Peptide, or Protein Immunologic Factor
Preferred_Name	HLA-DR Antigen
UMLS_CUI	C0019764
Legacy_Concept_Name	HLA-DR_Antigen
FULL_SYN	HLA-DR AntigenPTNCI HLA-DRSYNCI
DEFINITION	Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants.NCI
code	C16692
sameAs	HLA-DR Antigens
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0010477
is rdf:first of	nodeID://b730636
is rdfs:subClassOf of	HLA Class II Histocompatibility Antigen DRB HLA Class II Histocompatibility Antigen, DRB1-4 Beta Chain Protein
is someValuesFrom of	nodeID://b646424
is Has_Target of	Apolizumab
is sameAs of	HLA-DR Antigens HLA-DR Antigens

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