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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Apolizumab
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Apolizumab
NSC_Code
  • 704867
  • 710066
UMLS_CUI
  • C1122758
CAS_Registry
  • 267227-08-7
In_Clinical_Trial_For
  • Recurrent Hodgkins Lymphoma; Chronic Lymphocytic Leukemia; Small Lymphocytic Leukemia; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; B-cell Lymphoproliferative Disorders; Recurrent Non-Hodgkins Lymphoma.
FDA_UNII_Code
  • G88KCP51RE
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of hematologic (blood) cancers. Apolizumab binds to a protein called ID10, which is found on the surface of some types of immune cells and cancer cells. It may help the immune system kill cancer cells. It is a type of monoclonal antibody.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38451
PDQ_Closed_Trial_Search_ID
  • 38451
Legacy_Concept_Name
  • Apolizumab
FULL_SYN
  • MoAb Hu1D10ABNCI
  • apolizumabPTNCI-GLOSSCDR0000045051
  • Monoclonal antibody 1D10SYNCI
  • Monoclonal Antibody Hu1D10SYNCI
  • 1D10 Anti-lymphoma AntibodySYNCI
  • APOLIZUMABPTFDAG88KCP51RE
  • RemitogenBRNCI
  • MoAb: Hu1D10SYDTPNSC0710066
  • ApolizumabPTNCI
DEFINITION
  • A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro. (NCI04)NCI
code
  • C2228
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