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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Liarozole
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Liarozole
UMLS_CUI
  • C0165479
CAS_Registry
  • 115575-11-6
FDA_UNII_Code
  • K0Q29TGV9Y
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that promotes differentiation by increasing the levels of retinoic acid within the tumor.NCI-GLOSS
Chemical_Formula
  • C17H13ClN4
Legacy_Concept_Name
  • Liarozole
FULL_SYN
  • 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-SNNCI
  • LiarozolePTDCP31430
  • LIAROZOLEPTFDAK0Q29TGV9Y
  • LiazalBRNCI
  • R 75251CNNCI
  • R-61405SYNCI
  • LiarozolePTNCI
  • liarozolePTNCI-GLOSSCDR0000045752
DEFINITION
  • An orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.NCI
code
  • C1433
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