About: Liarozole Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Liarozole Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Liarozole Hydrochloride
UMLS_CUI
  • C2697919
CAS_Registry
  • 145858-50-0
FDA_UNII_Code
  • 29T7S2IB97
Contributing_Source
  • FDA
Chemical_Formula
  • C17H13ClN4.HCl
Legacy_Concept_Name
  • Liarozole_Hydrochloride
FULL_SYN
  • 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, Monohydrochloride, (+-)-SNNCI
  • Liarozole HydrochloridePTNCI
  • Liarozole HClSYNCI
  • LIAROZOLE HYDROCHLORIDEPTFDA29T7S2IB97
  • (+-)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole MonohydrochlorideSNNCI
  • R 75251CNNCI
DEFINITION
  • The fumarate salt of an orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.NCI
code
  • C80333
is Has_Salt_Form of
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