About: Liarozole Fumarate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Liarozole Fumarate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Liarozole Fumarate
UMLS_CUI
  • C0245820
CAS_Registry
  • 145858-52-2
FDA_UNII_Code
  • 91W7VLK7J3
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41252
PDQ_Closed_Trial_Search_ID
  • 41252
Chemical_Formula
  • 2C17H13ClN4.3C4H4O4
Legacy_Concept_Name
  • Liarozole_Fumarate
FULL_SYN
  • (+-)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole Fumarate (2:3)SNNCI
  • R85246CNNCI
  • Liarozole FumaratePTNCI
  • LIAROZOLE FUMARATEPTFDA91W7VLK7J3
  • 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, (+-)-, (E)-2-butenedioate (2:3)SNNCI
DEFINITION
  • The orally active fumarate salt of the benzimidazole derivative liarozole with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.NCI
code
  • C1524
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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