About: Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	CD148 is a receptor-like protein-tyrosine phosphatase inhibiting transduction of signals in non-hematopoietic cells. We describe striking differences in CD148 expression between human and murine thymocyte subsets, the only unifying feature being the absence of CD148 during the positive selection when the major developmental block occurs under CD45 deficiency. CD148 has both activating and inhibitory effects on the SFKs involved in TCR signaling. In the absence of CD45, activating effects prevail, resulting in functional complementation of CD45 deficiency in human T cell lines. This is independent of the tyrosines in the CD148 C-terminal tail, contradicting the recently proposed phosphotyrosine displacement model as a mechanism of SFK activation by CD148. Differential effects of CD148 in T cells and other leukocyte subsets cannot be explained by the CD148 inability to activate T cell SFKs but rather by its dual inhibitory/activatory function and specific expression pattern. CD148 is a receptor-like protein-tyrosine phosphatase inhibiting transduction of signals in non-hematopoietic cells. We describe striking differences in CD148 expression between human and murine thymocyte subsets, the only unifying feature being the absence of CD148 during the positive selection when the major developmental block occurs under CD45 deficiency. CD148 has both activating and inhibitory effects on the SFKs involved in TCR signaling. In the absence of CD45, activating effects prevail, resulting in functional complementation of CD45 deficiency in human T cell lines. This is independent of the tyrosines in the CD148 C-terminal tail, contradicting the recently proposed phosphotyrosine displacement model as a mechanism of SFK activation by CD148. Differential effects of CD148 in T cells and other leukocyte subsets cannot be explained by the CD148 inability to activate T cell SFKs but rather by its dual inhibitory/activatory function and specific expression pattern. (en)
Title	Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148 Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148 (en)
skos:prefLabel	Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148 Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148 (en)
skos:notation	RIV/68378050:_____/11:00370118!RIV12-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(1M0506), P(2B06064), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	25
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Brdička, Tomáš Hořejší, Václav Angelisová, Pavla Dráber, Peter Štěpánek, Ondřej Skopcová, Tereza
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	226279
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00370118
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CD148; tyrosine phosphatase; Src family kinases (en)
http://linked.open.../riv/klicoveSlovo	CD148 Src family kinases tyrosine phosphatase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[EB5D6B47F170]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Molecular and Cellular Immunology New target genes for childhood leukemia diagnosis and treatment focused on adaptor molecules of signaling pathways
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	286
http://linked.open...iv/tvurceVysledku	Angelisová, Pavla Brdička, Tomáš Hořejší, Václav Weiss, A. Dráber, Peter Kalina, T. Skopcová, Tereza Svojgr, K. Štěpánek, Ondřej
http://linked.open...ain/vavai/riv/wos	000291719900016
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0021-9258
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/jbc.M110.196733
is http://linked.open...avai/riv/vysledek of	Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148 Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148

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