About: P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	P-bodies are centers of mRNA metabolism, where meet pathways linked to mRNA silencing and degradation. So far, P-bodies were found in all examined mammalian cells.Here, we show an unexpected and important discovery that P-bodies disappear from oocztes at the beginning of their growth phase and appear again only in the early embryo. P-body decay likely reflects the requirement stabiliyation and storage of maternal mRNAs, which will govern development until the zygotc expression takes over. In addition, we were the first to show that stored maternal mRNAs do not have a homogeneous distribution. Instead, they localize to the periphery – cortex. P-bodies are centers of mRNA metabolism, where meet pathways linked to mRNA silencing and degradation. So far, P-bodies were found in all examined mammalian cells.Here, we show an unexpected and important discovery that P-bodies disappear from oocztes at the beginning of their growth phase and appear again only in the early embryo. P-body decay likely reflects the requirement stabiliyation and storage of maternal mRNAs, which will govern development until the zygotc expression takes over. In addition, we were the first to show that stored maternal mRNAs do not have a homogeneous distribution. Instead, they localize to the periphery – cortex. (en)
Title	P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes (en)
skos:prefLabel	P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes (en)
skos:notation	RIV/68378050:_____/10:00346838!RIV11-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ME09039), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Flemr, Matyáš Svoboda, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	278325
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00346838
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	oocyte; mRNA; cortex (en)
http://linked.open.../riv/klicoveSlovo	cortex oocyte mRNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0CE0C4E8AEA3]
http://linked.open...i/riv/nazevZdroje	Biology of Reproduction
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of post-transtranional mechanisms in reprogramming of mouse oocytes into pluripotent cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Svoboda, Petr Ma, J. Flemr, Matyáš Schultz, R. M.
http://linked.open...ain/vavai/riv/wos	000276867800023
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0006-3363
number of pages	10 (xsd:int)
is http://linked.open...avai/riv/vysledek of	P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes

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