About: WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases

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About: WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P)H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1. The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P)H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1. (en) Krystalová struktura flavodoxinu podobného proteinu WrbA s navázaným FMN odhaluje blízkou struturní příbuznost s eukariotními NAD(P)H zavislými chinon oxidoreduktasami, Nqo1. Porovnání krystalových struktur WrbA, Flavodoxinu a Nqo1 ukazuje jak je stočená otevřená struktura beta skládaného listu uspořádána tak, aby vznikl multimer, který rozšiřuje katalitickou funkci z jednoelektronového přenosu na dvouelektronový. Strukturní analýza naznačuje možné nové fyziologické funkce proteinů WrbA a Nqo1. (cs)
Title	WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases Protein WrbA tvoří most mezi bakterialními Flavodoxiny a eukariotními NAD(P)H zavislými chinon oxidoreduktasami (cs) WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases (en)
skos:prefLabel	WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases Protein WrbA tvoří most mezi bakterialními Flavodoxiny a eukariotními NAD(P)H zavislými chinon oxidoreduktasami (cs) WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases (en)
skos:notation	RIV/68378050:_____/07:00097983!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany	2301;2305
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514), Z(AV0Z60870520)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Brynda, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	461426
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/07:00097983
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	WrbA; crystal structure; Nqo1; oxidoreductases (en)
http://linked.open.../riv/klicoveSlovo	oxidoreductases Nqo1 crystal structure WrbA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BF54D3647B58]
http://linked.open...i/riv/nazevZdroje	Protein Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Ettrich, Rüdiger Kutá-Smatanová, Ivana Carey, J. Wolfová, Julie Grandori, R. Gustavsson, T.
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Spatial and functional dynamics of biological, ecological and socio-economic systems interacting with global climatic change
issn	0961-8368
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases WrbA bridges bacterial flavonoids and eukaryotic NAD(P)H:quinone oxidoreductases

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