About: Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the study was to find whether probiotic Lactobacillus casei influences the expression or the activity of cytochromes P450 (CYP) and whether it has an influence on the level of CYP mRNA in male rats. Live bacterial suspension of l. casei was administered orally (gavage)to healthy male Wistar rats daily for 7 days. Control group of rats was treated with the saline solution. Sections of the duodenum, jejunum, ileum, caecum and colon were dissected from each experimental animal. In all individuai samples, the expression of selected CYPs was determined by Western blotting. The levels of expression of CYPs were also evaluated by mRNA using the real-time PCR method The aim of the study was to find whether probiotic Lactobacillus casei influences the expression or the activity of cytochromes P450 (CYP) and whether it has an influence on the level of CYP mRNA in male rats. Live bacterial suspension of l. casei was administered orally (gavage)to healthy male Wistar rats daily for 7 days. Control group of rats was treated with the saline solution. Sections of the duodenum, jejunum, ileum, caecum and colon were dissected from each experimental animal. In all individuai samples, the expression of selected CYPs was determined by Western blotting. The levels of expression of CYPs were also evaluated by mRNA using the real-time PCR method (en)
Title	Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats (en)
skos:prefLabel	Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats (en)
skos:notation	RIV/68378041:_____/11:00375540!RIV12-AV0-68378041
http://linked.open...avai/predkladatel	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(ED0030/01/01), P(GA305/08/0535), P(GD303/09/H048), S, Z(AV0Z50200510), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zídek, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	196644
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/11:00375540
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	probiotics; l. casei; cytochromes P450 (en)
http://linked.open.../riv/klicoveSlovo	probiotics cytochromes P450 l. casei
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[B2B584DAC77F]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources Molecular mechanisms of selected pathological processes in the cell Interference of probiotics with factors determining pharmacokinetics of drugs
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Tlaskalová-Hogenová, Helena Zídek, Zdeněk Anzenbacher, P. Anzenbacherová, E. Matušková, Z. Tunková, A. Zachařová, A. Šiller, M.
http://linked.open...ain/vavai/riv/wos	000300544100002
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0172-780X
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats Effects of Lactobacillus casei on the expression and the activity of cytochromes P450 and on the CYP mRNA level in the intestine and the liver of male rats

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