About: Biomedicine for regional development and human resources

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=ED0030/01/01
Description	The aim is to establish a new institute, technological infrastructure anad platform for molecularly-oriented basic and translantional biomedical research, aiming at better understanding of molecular bases of cancer and infectious diseases, leading to discovery of new biomarkers and therapeutic targets, folowed by validation of biological activities of small molecules identified in high-throughput screening, preclinical resting and proof-of concept clinical trials. Infrastructural part of the project will concentrate in common platform individual core facilities with unique technologies. (en) Cílem je zřídit nový ústav, technologickou infrastrukturu a platformu pro molekulárně orientovaný základní a translační biomedicinský výzkum, s cílem lépe porozumět molekulární podstatě nádorových a infekčních onemocnění. Výzkum by měl vést k identifikaci nových biomarkerů a terapeutických cílů, hodnocení biologické aktivity malých molekul pomocí vysoce kapacitních skríningových testů, preklinického vývoje, v ojedinělých případech dotažení až do fáze časných ověřovacích klinických zkoušek typu proof-of-concept. Infrastrukturální část projektu bude soustřeďovat v jednotné platformě jednotlivé %22core facilities%22 s jedinečnými technologiemi.
Title	Biomedicine for regional development and human resources (en) Biomedicína pro regionální rozvoj a lidské zdroje
skos:notation	ED0030/01/01
http://linked.open...avai/cep/aktivita	Operational Programme Research and Development for Innovation
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/ED0030%2F01%2F01/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/ED0030%2F01%2F01/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-04-02 (xsd:date)
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100455431
http://linked.open...ai/cep/hlavniObor	EB - Genetika a molekulární biologie
http://linked.open...vai/cep/kategorie	IF - Infrastruktura výzkumu a vývoje
http://linked.open.../cep/klicovaSlova	biomedical research, cancer and infectious diseases (en)
http://linked.open...ep/partnetrHlavni	Lékařská fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	1 (xsd:int)
http://linked.open.../pocetVysledkuRIV	274 (xsd:int)
http://linked.open...enychVysledkuVRIV	274 (xsd:int)
http://linked.open...lneniVMinulemRoce	2013-01-31 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/0030%2F01%2F01
http://linked.open...iciPoslednihoRoku	2014
http://linked.open...atUdajeProjZameru	2014
http://linked.open...usZobrazovaneFaze	DRRVK
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2014-03-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CC - Organická chemie FR - Farmakologie a lékárnická chemie
http://linked.open...ep/zahajeniReseni	2010-03-29 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBBBK
http://linked.open.../cep/klicoveSlovo	biomedical research
is http://linked.open...vavai/riv/projekt of	The effect of acetylsalicylic acid on angiogenesis in vitro Dynamics and Organization of Cortical Microtubules as Revealed by Superresolution Structured Illumination Microscopy Dosage Compensation of an Aneuploid Genome in Mouse Spermatogenic Cells MKK7 and ARF New players in the DNA damage response scenery Oxidation of Endogenous N-Arachidonoylserotonin by Human Cytochrome P450 2U1 Patterns of DNA damage response in intracranial germ cell tumors versus glioblastomas reflect cell of origin rather than brain environment: Implications for the anti-tumor bather concept and treatment Epstein-Barr virus, the germinal centre and the development of Hodgkin's lymphoma Effects of Anthocyanidins and Anthocyanins on the Expression and Catalytic Activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in Primary Human Hepatocytes and Human Liver Microsomes Hepcidin levels in Diamond-Blackfan anemia reflect erythropoietic activity and transfusion dependency Gene expression profiling after angiogenesis inhibitor treatment Malignant Melanoma in The Czech Republic: Incidence and Mortality According to Sex, Age and Disease Stage Magnetically Assisted Surface-Enhanced Raman Scattering Selective Determination of Dopamine in an Artificial Cerebrospinal Fluid and a Mouse Striatum Using Fe3O4/Ag Nanocomposite TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage Presence og gnr genes in ESBL-positive isolates of Klebsiella pneumoniae Význam biomarkerů pro indikaci cílené biologické léčby v onkologii Effect of ultrasound on efficiency of photodynamic therapy - in vitro study A Novel Semisynthetic Flavonoid 7-O-Galloyltaxifolin Upregulates Heme Oxygenase-1 in RAW264.7 Cells via MAPK/Nrf2 Pathway A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response Biotransformation of Silybin and its Congeners Association study in Romanians confirms IL23A gene haplotype block rs2066808/rs11171806 as conferring risk to psoriatic arthritis ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA Correlation between BRCA1 expression and clinicopathological factors including brain metastases in patients with non-small-cell lung cancer The epidemiology of thyroid cancer in the Czech Republic in comparison with other countries Effects of glucocorticoids on cytochrome P450 1A1 (CYP1A1) expression in isolated human placental trophoblast The energetic difference between synthesis of correct and incorrect base pairs accounts for highly accurate DNA replication The effect of photodynamic treatment on the morphological and mechanical properties of the HeLa cell line Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage Karcinom cervixu - možnosti detekce lidského papilomaviru IX. Diagnostic, Predictive and Experimetnal Oncology Days JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks N-glycoprotein SRMAtlas: a resource of mass spectrometric assays for N-glycosites enabling consistent and multiplexed protein quantification for clinical applications Usage of survival analysis in biomedicine and engineering Oxidační stres u pacientů po transplantaci ledviny Overabundant FANCD2, alone and combined with NQO1, is a sensitive marker of adverse prognosis in breast cancer Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors Safety and Efficacy of Endovascular Sonolysis Using the EkoSonic Endovascular System in Patients with Acute Stroke Analysis of ancient DNA. Application of wet effluent diffusion denuder for measurement of uptake coefficient of gaseous pollutants Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2 Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDP-glucuronosyltransferases Epithelial Junction Opener JO-1 Improves Monoclonal Antibody Therapy of Cancer Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia Flexibility of human cytochrome p450 enzymes: Molecular dynamics and spectroscopy reveal important function-related variations Fluorescence properties of some 2-(4-aminosubstituted-3-nitrophenyl)-3-hydroxyquinolin-4(1H)-ones Fluorescent probe for the pH determination Interaction of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates with human liver microsomal cytochromes P450: comparison with free doxorubicin In vitro interaction of a novel neutrophil growth factor with human liver microsomal cytochromes P450 and the contribution of UDP-glucuronosyltransferases to its metabolism Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines In vitro cytotoxicity and phototoxicity study of cosmetics colorants More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance Osteoblast and gingival fibroblast markers in dental implant studies. The Potential of Triterpenoids in the Treatment of Melanoma The potential of high resolution melting analysis (HRMA) to streamline, facilitate and enrich routine diagnostics in medical microbiology Using newly developed multiplex polymerase chain reaction and meltingcurve analysis for detection and discrimination of beta-lactamases in Escherichia coli isolates from intensive care patients Two new CHEK2 germ-line variants detected in breast cancer/sarcoma families negative for BRCA1, BRCA2, and TP53 gene mutations Vyšetření mutačního statutu genu KRAS jako součást algoritmu léčby metastatického kolorektálního karcinomu WNT signaling in prostate development and carcinogenesis Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas Acinetobacter baumannii carrying the OXA-23 gene in the Czech Republic An Interesting Synthetic Pathway to Some Quinolin-4(1H)ones: Phenacylanthranilates Rearrangement - Limits and Scopes Bile acid-cysteamine conjugates: Structural properties, gelation, and toxicity evaluation Biomarkers in the detection of minimal systemic dissemination in lung cancer patients

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