About: Functional analysis of the skin-swelling response to phytohaemagglutinin

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The phytohaemagglutinin (PHA) skin-swelling test is widely used in immunoecology and ecotoxicology to estimate cell-mediated immunity presumed to reveal T-cell mediated immunocompetence. To investigate the mechanism triggering this response we have compared in zebra finch (Taeniopygia guttata) the immune responses to two PHA isolectins (PHA-L and PHA-E) differing in their biological properties and one control protein. This is the first study to show the importance of erythroagglutination in the development of an inflammatory response to PHA-P. Our results indicate that the skin-swelling test using PHA-P reliably mirrors the individual general proinflammatory potential. The immunological background of the test is highly complex and the test results cannot be interpreted as measurements of the adaptive immunity or T-cell activity. This interpretational change importantly alters our view on the test results regarding the costs of the response or the evolutionary immunological adaptations. The phytohaemagglutinin (PHA) skin-swelling test is widely used in immunoecology and ecotoxicology to estimate cell-mediated immunity presumed to reveal T-cell mediated immunocompetence. To investigate the mechanism triggering this response we have compared in zebra finch (Taeniopygia guttata) the immune responses to two PHA isolectins (PHA-L and PHA-E) differing in their biological properties and one control protein. This is the first study to show the importance of erythroagglutination in the development of an inflammatory response to PHA-P. Our results indicate that the skin-swelling test using PHA-P reliably mirrors the individual general proinflammatory potential. The immunological background of the test is highly complex and the test results cannot be interpreted as measurements of the adaptive immunity or T-cell activity. This interpretational change importantly alters our view on the test results regarding the costs of the response or the evolutionary immunological adaptations. (en)
Title	Functional analysis of the skin-swelling response to phytohaemagglutinin Functional analysis of the skin-swelling response to phytohaemagglutinin (en)
skos:prefLabel	Functional analysis of the skin-swelling response to phytohaemagglutinin Functional analysis of the skin-swelling response to phytohaemagglutinin (en)
skos:notation	RIV/68081766:_____/10:00342466!RIV11-GA0-68081766
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA206/08/0640), P(GA206/08/1281), P(LC06073), Z(AV0Z60930519), Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Albrecht, Tomáš Vinkler, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav biologie obratlovců AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	259932
http://linked.open...ai/riv/idVysledku	RIV/68081766:_____/10:00342466
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	avian innate and adaptive immunity; ecoimmunology; ecological immunology; ecotoxicology; inflammatory response; PHA-induced hypersensitivity; phytohaemagglutinin; T-cell-mediated immunocompetence (en)
http://linked.open.../riv/klicoveSlovo	inflammatory response ecoimmunology ecological immunology phytohaemagglutinin ecotoxicology PHA-induced hypersensitivity T-cell-mediated immunocompetence avian innate and adaptive immunity
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2B5ABB5E70AE]
http://linked.open...i/riv/nazevZdroje	Functional Ecology
http://linked.open...in/vavai/riv/obor	EG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunogenetic study of a house mouse hybrid zone Biodiversity Research Center Components of sexual selection in the monogamous Grey Partridge
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Albrecht, Tomáš Vinkler, Michal Bainová, H.
http://linked.open...ain/vavai/riv/wos	000281895800016
http://linked.open...n/vavai/riv/zamer	Biodiverzita a ekologie obratlovců: Strategie ochrany a využívání přírodních populací Ekologické procesy v evoluci modelových skupin organismů
issn	0269-8463
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Functional analysis of the skin-swelling response to phytohaemagglutinin

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