About: Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]

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About: Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)] Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The photocytotoxicity and photobiochemical properties of the new complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)(piperidine)] are compared with its analogue containing the less basic and less lipophilic ligand pyridine. The results indicate that the piperidine complex has a more rapid rate of light activation to cytotoxic species but in other cellular and biochemical aspects its behavior is similar to that of pyridine analogue. The photocytotoxicity and photobiochemical properties of the new complex trans,trans,trans-[Pt(N3)2(OH)2(NH3)(piperidine)] are compared with its analogue containing the less basic and less lipophilic ligand pyridine. The results indicate that the piperidine complex has a more rapid rate of light activation to cytotoxic species but in other cellular and biochemical aspects its behavior is similar to that of pyridine analogue. (en)
Title	Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)] Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)] (en)
skos:prefLabel	Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)] Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)] (en)
skos:notation	RIV/68081707:_____/11:00368775!RIV12-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP301/10/0598), P(GD301/09/H004), P(IAA400040803), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Brabec, Viktor Zerzánková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	204541
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00368775
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	platinum azides; cisplatin; photoactivation (en)
http://linked.open.../riv/klicoveSlovo	photoactivation platinum azides cisplatin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2AA800C8EC41]
http://linked.open...i/riv/nazevZdroje	Journal of Inorganic Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer Mechanistic studies related to targeted cancer chemotherapy with light-activated platinum and ruthenium antitumor agents
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Sadler, P. J. Zerzánková, Lenka Bednarski, P. J. Salassa, L. Westendorf, A. F.
http://linked.open...ain/vavai/riv/wos	000290923100009
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0162-0134
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jinorgbio.2011.01.003
is http://linked.open...avai/riv/vysledek of	Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)] Influence of pyridine versus piperidine ligands on the chemical, DNA binding and cytotoxic properties of light activated trans,trans,trans-[Pt(N3)2(OH)2(NH3)(L)]

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