About: Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations     Goto   Sponge   Distinct   Permalink

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Description
  • The thrombin-binding aptamer (15-TBA) is a 15-mer DNA oligonucleotide with sequence d(GGTTGGTGTGGTTGG). 15-TBA folds into a quadruplex DNA (G-DNA) structure with two planar G-quartets connected by three single-stranded loops. In the present study, the explicit solvent molecular dynamics (MD) simulation method was utilized to analyze the 15-TBA-thrombin threedimensional structure.
  • The thrombin-binding aptamer (15-TBA) is a 15-mer DNA oligonucleotide with sequence d(GGTTGGTGTGGTTGG). 15-TBA folds into a quadruplex DNA (G-DNA) structure with two planar G-quartets connected by three single-stranded loops. In the present study, the explicit solvent molecular dynamics (MD) simulation method was utilized to analyze the 15-TBA-thrombin threedimensional structure. (en)
Title
  • Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations
  • Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations (en)
skos:prefLabel
  • Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations
  • Structural dynamics of thrombin-binding DNA aptamer d(GGTTGGTGTGGTTGG) quadruplex DNA studied by large-scale explicit solvent simulations (en)
skos:notation
  • RIV/68081707:_____/10:00373422!RIV12-MSM-68081707
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA203/09/1476), P(IAA400040802), P(LC06030), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika
  • 10
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 290437
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/10:00373422
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • molecular dynamics; quadruplex DNA; thrombin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [FF620D09B1E0]
http://linked.open...i/riv/nazevZdroje
  • Journal of Chemical Theory and Computation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...v/svazekPeriodika
  • 6
http://linked.open...iv/tvurceVysledku
  • Šponer, Jiří
  • Golovin, A.
  • Kopylov, A.
  • Reshetnikov, R.
  • Spiridonova, V.
http://linked.open...ain/vavai/riv/wos
  • 000282840600001
http://linked.open...n/vavai/riv/zamer
issn
  • 1549-9618
number of pages
http://bibframe.org/vocab/doi
  • 10.1021/ct100253m
is http://linked.open...avai/riv/vysledek of
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