About: Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix.

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About: Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The stabilization of DNA can be affected by all the types of chemical modifications of DNA (interstrand cross-links, intrastrand cross-links or monofunctional adducts) which give rise to a strong enough local stabilization of the double helix. Our calculation demonstrates that an increase in stability by 25 to 30 kcal in the free energy of a single base pair of the double helix is sufficient for conserving the helicity of this base pair and preventing strand separation after melting of ordinary base pairs. For the situation where there is more then one stabilized site in a DNA duplex, a lower stabilization per site is sufficient (18 - 20 kcal). A substantial increase in DNA stability was found in various experimental studies for some metal-based antitumor compounds. Stretches of GC pairs more than 25 bp in length inserted into poly(AT) DNA also exhibit properties of stabilizing interstrand cross-links. The stabilization of DNA can be affected by all the types of chemical modifications of DNA (interstrand cross-links, intrastrand cross-links or monofunctional adducts) which give rise to a strong enough local stabilization of the double helix. Our calculation demonstrates that an increase in stability by 25 to 30 kcal in the free energy of a single base pair of the double helix is sufficient for conserving the helicity of this base pair and preventing strand separation after melting of ordinary base pairs. For the situation where there is more then one stabilized site in a DNA duplex, a lower stabilization per site is sufficient (18 - 20 kcal). A substantial increase in DNA stability was found in various experimental studies for some metal-based antitumor compounds. Stretches of GC pairs more than 25 bp in length inserted into poly(AT) DNA also exhibit properties of stabilizing interstrand cross-links. (en)
Title	Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. (en)
skos:prefLabel	Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. Melting of cross-linked DNA V. Cross-linking effect caused by local stabilization of the double helix. (en)
skos:notation	RIV/68081707:_____/03:17033293!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany	533;545
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1552), P(IAA5004101), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	614784
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033293
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cross-links; double helix; DNA (en)
http://linked.open.../riv/klicoveSlovo	DNA cross-links double helix
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[55612E866757]
http://linked.open...i/riv/nazevZdroje	Journal of Biomolecular Structure and Dynamics
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Fridman, A. S. Haroutiunian, S. G. Lando, D. Y. Wartell, R. M.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0739-1102
number of pages	13 (xsd:int)

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