About: DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media.

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About: DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media. Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Modifications of natural DNA in a cell-free medium by antitumor monodentate Ru(II) arene compounds of the general formula [(6-arene)Ru(en)Cl]+ (arene = biphenyl, dihydroanthracene, tetrahydroanthracene, p-cymene, or benzene; en = ethylenediamine) were studied. The results indicate that these complexes bind preferentially to guanine residues in double-helical DNA. The data are consistent with DNA binding of the complexes containing biphenyl, dihydroanthracene, or tetrahydroanthracene ligands that involves combined coordination to G N7 and noncovalent interactions between the arene ligand and DNA. The single hydrocarbon rings in the p-cymene and benzene ruthenium complexes cannot interact with DNA by intercalation. It has been suggested that the different character of conformational alterations induced in DNA may affect differently further downstream effects of damaged DNA and may result in different biological effects of this new class of antitumor compounds. Modifications of natural DNA in a cell-free medium by antitumor monodentate Ru(II) arene compounds of the general formula [(6-arene)Ru(en)Cl]+ (arene = biphenyl, dihydroanthracene, tetrahydroanthracene, p-cymene, or benzene; en = ethylenediamine) were studied. The results indicate that these complexes bind preferentially to guanine residues in double-helical DNA. The data are consistent with DNA binding of the complexes containing biphenyl, dihydroanthracene, or tetrahydroanthracene ligands that involves combined coordination to G N7 and noncovalent interactions between the arene ligand and DNA. The single hydrocarbon rings in the p-cymene and benzene ruthenium complexes cannot interact with DNA by intercalation. It has been suggested that the different character of conformational alterations induced in DNA may affect differently further downstream effects of damaged DNA and may result in different biological effects of this new class of antitumor compounds. (en)
Title	DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media. DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media. (en)
skos:prefLabel	DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media. DNA interactions of monofuntional organometallic ruthenium(II) antitumor complexes in cell-free media. (en)
skos:notation	RIV/68081707:_____/03:17033053!RIV/2004/MSM/A17004/N
http://linked.open.../vavai/riv/strany	11544;11554
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/01/0418), P(GA305/02/1552), P(IAA5004101), P(OC D20.002), P(OC D20.005), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika	39
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brabec, Viktor Nováková, Olga Vrána, Oldřich
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	604243
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:17033053
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	double-helical DNA; interstrand cross-links; biophysical analysis (en)
http://linked.open.../riv/klicoveSlovo	double-helical DNA interstrand cross-links biophysical analysis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E0FE601F8863]
http://linked.open...i/riv/nazevZdroje	Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20D20.005 http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20D20.002 Cellular and molecular pharmakology of platinum and ruthenium anticancer drugs Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Structure, recognition and biochemistry of DNA modified by antitumor platinum drugs
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	42
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Chen, H. Sadler, P. J. Nováková, Olga Vrána, Oldřich Rodger, A.
http://linked.open...n/vavai/riv/zamer	Biophysical properties of living systems and their changes under the influence of environmental factors
issn	0006-2960
number of pages	11 (xsd:int)

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