About: Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53.     Goto   Sponge   Distinct   Permalink

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Description
  • Binding of active, latent and in vitro-activated p53 protein to DNA fragments globally modified by antitumor cisplatin was studied using electrophoretic mobility shift assay in agarose gels and immunoblotting analysis. Both latent and active p53 forms bound to platinated random sequences of DNA with a higher affinity than to unmodified DNA. The latent form exhibited a more pronounced selectivity for platinated DNA than the active p53.
  • Binding of active, latent and in vitro-activated p53 protein to DNA fragments globally modified by antitumor cisplatin was studied using electrophoretic mobility shift assay in agarose gels and immunoblotting analysis. Both latent and active p53 forms bound to platinated random sequences of DNA with a higher affinity than to unmodified DNA. The latent form exhibited a more pronounced selectivity for platinated DNA than the active p53. (en)
Title
  • Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53.
  • Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53. (en)
skos:prefLabel
  • Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53.
  • Recognition of DNA modified by antitumor cisplatin by 'latent' and 'active' protein p53. (en)
skos:notation
  • RIV/68081707:_____/03:17033016!RIV/2004/AV0/A17004/N
http://linked.open.../vavai/riv/strany
  • 1305;1316
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA204/02/0734), P(GA301/00/P094), P(GA301/02/0831), P(GA305/01/0418), P(GA305/02/1552), P(IBS5004009), P(NC5343), P(NC7131), P(NL6058), Z(AV0Z5004920)
http://linked.open...iv/cisloPeriodika
  • 8
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 624818
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/03:17033016
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • tumor suppressor protein p53; latent p53; antitumor drugs (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [67705ED35661]
http://linked.open...i/riv/nazevZdroje
  • Biochemical Pharmacology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 65
http://linked.open...iv/tvurceVysledku
  • Brabec, Viktor
  • Brázdová, Marie
  • Kašpárková, Jana
  • Paleček, Emil
  • Pospíšilová, Š.
  • Pivoňková, Hana
  • Kovářová, Lucie
  • Vojtěšek, B.
  • Fojta, Miloslav
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-2952
number of pages
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