About: The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles

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About: The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Our results show that only the M2 subtype is present in the atria. In the ventricles, however, we were able to determine that 20% (on average) of the muscarinic receptors were subtypes other than M2, with the majority of these belonging to the M1 subtype. We were also able to detect a marginal fraction (62%) of receptors that, based on other findings, belong mainly to the M5 muscarinic receptors. Co-treatment with MT7 and AQ-RA 741 was not a suitable tool for blocking of M1–M4 receptors and can not therefore be used as a method for M5 muscarinic receptor detection in substitution to crude venom. These results provide further evidence of the expression of the M1 muscarinic receptor subtype in the rat heart and also show that the heart contains at least one other, albeit minor, muscarinic receptor population, which most likely belongs to the M5 muscarinic receptors but not to that of the M3 receptors Our results show that only the M2 subtype is present in the atria. In the ventricles, however, we were able to determine that 20% (on average) of the muscarinic receptors were subtypes other than M2, with the majority of these belonging to the M1 subtype. We were also able to detect a marginal fraction (62%) of receptors that, based on other findings, belong mainly to the M5 muscarinic receptors. Co-treatment with MT7 and AQ-RA 741 was not a suitable tool for blocking of M1–M4 receptors and can not therefore be used as a method for M5 muscarinic receptor detection in substitution to crude venom. These results provide further evidence of the expression of the M1 muscarinic receptor subtype in the rat heart and also show that the heart contains at least one other, albeit minor, muscarinic receptor population, which most likely belongs to the M5 muscarinic receptors but not to that of the M3 receptors (en)
Title	The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles (en)
skos:prefLabel	The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles (en)
skos:notation	RIV/67985823:_____/08:00338075!RIV10-MSM-67985823
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA304/08/0256), P(LC554), S, Z(AV0Z50110509), Z(MSM0021620849)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Říčný, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	362847
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/08:00338075
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	heart; muscarinic receptors; PLC activity (en)
http://linked.open.../riv/klicoveSlovo	muscarinic receptors heart PLC activity
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[CAA29FA7AD1C]
http://linked.open...i/riv/nazevZdroje	Naunyn-Schmiedeberg's Archiv of Pharmacology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulation of muscle phenotype under normal, experimental and pathological conditions Neuroscience Centre
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	378
http://linked.open...iv/tvurceVysledku	Říčný, Jan Klein, M. Nováková, M. Mysliveček, J.
http://linked.open...ain/vavai/riv/wos	256929400011
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Neuropsychiatrické aspekty neurodegenerativních onemocnění
issn	0028-1298
number of pages	14 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles

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