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| Description
| - Výzkumný záměr si klade za cíl studovat etiopatogenetické mechanismy závažných neurodegenerativních chorob jako jsou Alzheimerova a Parkinsonova nemoc, ale také roztroušená sklerosa, demyelinisační onemocnění, u nějž se nově zjišťuje významný podíl neurodegenerativních dějů. Budeme zjišťovat podíl biologických podkladů a vlivů zevního prostředí na vzniku těchto onemocnění, na jejich klinickém vyjádření a způsobech rozvoje, včetně sledování strukturálních změn mozku a funkčních korelátů těchto poruch. Zaměříme se na studium genetických a jiných faktorů ovlivňujících výsledky a bezpečnost léčby novějšími farmaky a dalšími moderními biologickými metodami, které máme k disposici (např. repetitivní transkraniální magnetická stimulace a chronická hluboká mozková stimulace). Získané poznatky budeme využívat při vývoji a doporučení nových, individualizovaných terapeutických postupů, které v dlouhodobé perspektivě mohou podstatně snížit zdravotní zátěž těchto těžce postižených a trpících pacientů.
- The goal of this research project is to study etiopathogenetic mechanisms of serious neurodegenerative disorders such as Alzheimer´s and Parkinson´s diseases but also multiple sclerosis, a demyelinating disorder where neurodegeneration is now recognized as one of the major underlying processes. We will study biological and environmental factors underlying neurodegeneration, its clinical manifestations and the ways of progression including brain structural changes and functional correlates. We will study genetic and other factors influencing clinical outcome and safety of recently introduced drugs and biological methods (repetitive transcranial magnetic stimulation, chronic deep brain stimulation). Obtained results and knowledge will be used for development and introduction of new, individualized therapeutic approaches, which in long-term perspective may decrease disease burden in seriously disabled and suffering patients. (en)
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| Title
| - Neuropsychiatrické aspekty neurodegenerativních onemocnění
- Neuropsychiatric aspects of neurodegenerative diseases (en)
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ez/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...vavai/cez/dodavka
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| http://linked.open...ez/duvernostUdaju
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| http://linked.open...in/vavai/cez/faze
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| http://linked.open...ai/cez/hlavniObor
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| http://linked.open...vai/cez/hodnoceni
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| http://linked.open.../cez/kategorieVaV
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| http://linked.open.../cez/klicovaSlova
| - neurodegenerative diseases (en)
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| http://linked.open...cez/partnerHlavni
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| http://linked.open...z/poceVysledkuRIV
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cez/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open.../vavai/cez/resort
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ez/ukonceniReseni
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| http://linked.open...ez/zahajeniReseni
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| http://linked.open...n/vavai/cez/zamer
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| http://linked.open...sledkuDodavatelem
| - Vysoko je nutno hodnotit pokrok v nalezení potenciálních praktických výstupů základního výzkumu, zejména v oblasti biomarkerů neurodegenerativních onemocnění a kvantitativního hodnocení MRI u roztroušené sklerozy. Stejně tak je nutno vysoce hodnotit rozsáhlé a v několika případech vysoce prestižní publikační uplatnění výsledků a úspěšnou výchovu velkého počtu doktorandů. (cs)
- Highly appreciated are achievements in finding potential practical outputs of basic research. These comprise mainly biomarkers of neurodegenerative diseases, and quantitative MRI assessment in multiple sclerosis. Highly appreciated as well are numerous and in some instances highly prestigious (Lancet) publications, and successful education of numerous PhD. students. (en)
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| http://linked.open...cez/zivotniCyklus
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| is http://linked.open...n/vavai/riv/zamer
of | - Dissociative symptoms reflect levels of tumor necrosis factor alpha in patients with unipolar depression
- Effect of daclizumab high-yield process in patients with highly active relapsing-remitting multiple sclerosis
- Disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with daclizumab high-yield process in the SELECT study
- MR vyšetření penisu u pacienta s priapismem
- Plasma homocysteine in Alzheimer's disease with or without co-morbid depressive symptoms
- Effects of BG-12 (dimethyl fumarate) on health-related quality of life in patients with relapsing-remitting multiple sclerosis: findings from the CONFIRM study
- Efficacy and safety of BG-12 (dimethyl fumarate) and other disease-modifying therapies for the treatment of relapsing-remitting multiple sclerosis: a systematic review and mixed treatment comparison
- Energy metabolism in patients with depression and Alzheimer's disease
- GSK3 beta, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
- Grooved Pegboard Predicates More of Cognitive Than Motor Involvement in Parkinson's Disease
- From pyridinium-based to centrally active acetylcholinesterase reactivators
- Managing flushing and gastrointestinal events associated with delayed-release dimethyl fumarate: Experiences of an international panel
- Effect of mitogen lectin on lymphocyte or brain cortex cell activation
- PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
- Heart valve abnormalities in Parkinson's disease treated with dopamine agonists
- Analysis of parasuicide, psychiatric care and completed suicides, implications for intervention strategy (Czech Republic, 1996-2000)
- I pacienti se schizofrenií mohou být fit: Roční výsledky Programu pro dobré zdraví v České republice
- Handedness does not predict side of onset of motor symptoms in Parkinson's disease
- Zájem o zdravý životní styl u psychotických onemocnění: Dotazníkové šetření mezi účastníky Programu pro dobré zdraví
- Projekt screeningu a krátké intervence v ordinaci praktického lékaře pro děti a dorost, vedoucí k snížení zneužívání návykových látek v adolescenci
- Tic-induced gait dysfunction
- Tremor-spectrum in spinocerebellar ataxia type 3
- Volumetric MRI Markers and Predictors of Disease Activity in Early Multiple Sclerosis: A Longitudinal Cohort Study
- Changes of cellular energy metabolism effected by psychotropic drugs and by psychiatric disorders
- Changes in cellular metabolism in patients with Alzheimer’s disease
- Bimonthly Evolution of Cortical Atrophy in Early Relapsing-Remitting Multiple Sclerosis over 2 Years : A Longitudinal Study
- Basal Ganglia Neuronal Activity during Scanning Eye Movements in Parkinson's Disease
- Asymmetric tonic neck reflex and symptoms of attention deficit and hyperactivity disorder in children
- Bayesian changepoint detection for the automatic assessment of fluency and articulatory disorders
- Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial
- Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase
- Deep-Brain Stimulation for Parkinson's Disease
- Control mechanisms in mitochondrial oxidative phosphorylation
- Demence s Lewyho tělísky
- Environmental Factors Associated with Disease Progression after the First Demyelinating Event: Results from the Multi-Center SET Study
- Interferon beta v současné léčbě roztroušené sklerózy
- Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes
- Introduction to Video-Clinical Corner
- Lipid profiles are associated with lesion formation over 24 months in interferon-beta treated patients following the first demyelinating event
- Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome
- Mycotic Spondylitis Caused by Cladosporium Cladosporides: a case report
- New Non-Linear Color Look-Up Table for Visualization of Brain Fractional Anisotropy Based on Normative Measurements - Principals and First Clinical Use
- Myasthenia gravis, castleman disease, pemphigus, and anti-phospholipid syndrome
- Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome
- Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies
- Narcolepsy: clinical differences and association with other sleep disorders in different age groups
- Neuropathic Pain, Depressive Symptoms, and C-Reactive Protein in Sciatica Patients
- Motor Matters: Tackling Heterogeneity of Parkinson’s Disease in Functional MRI Studies
- Plasma cortisol in Alzheimer's disease with or without depressive symptoms
- Parkinson's disease
- Pick and Alzheimer Diseases: A Rare Comorbidity Presenting as Corticobasal Syndrome
- Pathophysiology of Mood Disorders and Mechanisms of Action of Antidepressants and Mood Stabilizers
- Persisting primitive reflexes in medication-naive girls with attention-deficit and hyperactivity disorder
- Principle of Dissolution and Primitive Reflexes in ADHD
- Sex, Food and Threat: Startling Changes after Subthalamic Stimulation in Parkinson's Disease
- Development of a fast LC-MS/MS method for quantification of rilmenidine in human serum: elucidation of fragmentation pathways by HRMS
- Olfactory Dysfunction in Narcolepsy with and without Cataplexy
- An increase in substance misuse rather than other mental disorders has led to increased forensic treatment rates in the Czech Republic
- Komplikace léčby těžké spasticity implantabilními pumpovými systémy
- Magnetická rezonance nervové soustavy Radiologické a klinické aspekty II. Epilepsie neurodegenerativní onemocnění mozku
- Beneficial effect of deep brain stimulation of GPi in a patient with dystoniadeafness phenotype
- Dissociation, cognitive conflict and nonlinear patterns of heart rate dynamics in patients with unipolar depression
- Electrodermal complexity during the Stroop Colour Word Test
- Complex partial seizure-like symptoms and smoking in university students
- Dissociative symptoms and interregional EEG cross-correlations in paranoid schizophrenia
- Electrodermal dimensional complexity and smoking
- Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study
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