About: Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have recently demonstrated that the alkaloid colchicine (COL) inhibits glucocorticoid receptor (GR) transcriptional activity. In addition, we described proteasome-mediated degradation of GR in COL-treated HeLa cells. While these effects were previously attributed to cell cycle arrest in G2/M phase, this explanation is not applicable for nonproliferating cells such as human hepatocytes (HH). In the current study, we compared COL-mediated microtubule disruption and cell cycle arrest with selected GR functions in HeLa cells and HH as models of proliferating and quiescent cells, respectively. Microtubule disruption led to irreversible decrease in GR binding capacity and protein level in HeLa cells. We have recently demonstrated that the alkaloid colchicine (COL) inhibits glucocorticoid receptor (GR) transcriptional activity. In addition, we described proteasome-mediated degradation of GR in COL-treated HeLa cells. While these effects were previously attributed to cell cycle arrest in G2/M phase, this explanation is not applicable for nonproliferating cells such as human hepatocytes (HH). In the current study, we compared COL-mediated microtubule disruption and cell cycle arrest with selected GR functions in HeLa cells and HH as models of proliferating and quiescent cells, respectively. Microtubule disruption led to irreversible decrease in GR binding capacity and protein level in HeLa cells. (en)
Title	Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells (en)
skos:prefLabel	Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells (en)
skos:notation	RIV/61989592:15310/10:10217123!RIV11-GA0-15310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA303/07/0128), P(GAP304/10/0149), P(GP305/08/P089)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vrzal, Radim Dvořák, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	251324
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10217123
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microtubules; human hepatocytes; ERK; glucocorticoid receptor; colchicine (en)
http://linked.open.../riv/klicoveSlovo	ERK human hepatocytes colchicine microtubules glucocorticoid receptor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[F348BD367FB2]
http://linked.open...i/riv/nazevZdroje	International Journal of Toxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on tissue-specific aspects of transcriptional regulation of selected P-450 enzymes and drug transporters. Generation of hepatocyte-derived cellular models for preclinical testing of drugs The role of MAP kinases in cellular signalling of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk VRZAL, Radim GERBAL-CHALOIN, Sabine MAUREL, Patrick
http://linked.open...ain/vavai/riv/wos	000278124800011
issn	1091-5818
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15310
is http://linked.open...avai/riv/vysledek of	Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells Comparative Effects of Microtubules Disruption on Glucocorticoid Receptor Functions in Proliferating and Quiescent Cells

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