About: RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Bordetella pertussis adenylate cyclase toxin (CyaA, ACT, or AC-Hly) is a cytotoxin of the RTX (Repeat in ToXin) family. It delivers into target cells an adenylate cyclase domain that catalyzes uncontrolled conversion of ATP to cAMP, a key signaling molecule subverting phagocyte functions. CyaA utilizes a heavily N glycosylated B2 integrin receptor CD11b/CD18 (AMB2, Mac-1, or CR3). We show that deglycosylation of cell surface proteins by glycosidase treatment, or inhibition of protein N-glycosylation by tunicamycin, ablates CyaA binding and penetration of CD11b-expressing cells. Furthermore, binding of CyaA to cells was strongly inhibited in the presence of free saccharides occurring as building units of integrin oligosaccharide complex, while saccharides absent from integrin oligosaccharide chains failed to inhibit CyaA binding to CD11b/CD18-expressing cells Bordetella pertussis adenylate cyclase toxin (CyaA, ACT, or AC-Hly) is a cytotoxin of the RTX (Repeat in ToXin) family. It delivers into target cells an adenylate cyclase domain that catalyzes uncontrolled conversion of ATP to cAMP, a key signaling molecule subverting phagocyte functions. CyaA utilizes a heavily N glycosylated B2 integrin receptor CD11b/CD18 (AMB2, Mac-1, or CR3). We show that deglycosylation of cell surface proteins by glycosidase treatment, or inhibition of protein N-glycosylation by tunicamycin, ablates CyaA binding and penetration of CD11b-expressing cells. Furthermore, binding of CyaA to cells was strongly inhibited in the presence of free saccharides occurring as building units of integrin oligosaccharide complex, while saccharides absent from integrin oligosaccharide chains failed to inhibit CyaA binding to CD11b/CD18-expressing cells (en)
Title	RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides (en)
skos:prefLabel	RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides (en)
skos:notation	RIV/61388971:_____/08:00313812!RIV10-MSM-61388971
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(GP204/07/P105), P(IAA5020406), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Osička, Radim Morová, Jana Šebo, Peter Mašín, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	393531
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/08:00313812
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bordetella pertussis (en)
http://linked.open.../riv/klicoveSlovo	bordetella pertussis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[000D27E32F03]
http://linked.open...i/riv/nazevZdroje	Proceedings of the National Academy of Sciences of the United States of America
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Molecular and Cellular Immunology Study of the interaction of adenylate cyclase toxin with the integrin receptor CD11b/CD18 Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Osička, Radim Šebo, Peter Mašín, Jiří Morová, Jana
http://linked.open...ain/vavai/riv/wos	000254893600015
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0027-8424
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides RTX cytotoxins recognize Beta2 integrin receptors through N-linked oligosaccharides

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