About: Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.3109/09553002.2011.548437
Description	The large white pig is a useful experimental model to compare in vivo, in vitro and ex vivo sensitivity of peripheral blood leukocytes to ionizing radiation. We analysed dose- and time-dependent changes of lymphocyte and granulocyte absolute numbers. A flow cytometer were used to determine major leukocyte subpopulation numbers in blood samples after red cell removal. Similar to other species, lymphocyte numbers significantly decreased in pigs both in vivo and in vitro in a dose-dependent manner. Our data clearly show that reduction of lymphocyte numbers after irradiation in vivo proceeds much faster than after irradiation in vitro and that granulocyte changes depend only on the time of analysis after irradiation. All experimental arrangements demonstrated the radiosensitivity of lymphocytes and the radioresistance of peripheral blood granulocytes. These in vivo and in vitro approaches, as well as the newly introduced ex vivo observations, appear to be relevant to biodosimetry. The large white pig is a useful experimental model to compare in vivo, in vitro and ex vivo sensitivity of peripheral blood leukocytes to ionizing radiation. We analysed dose- and time-dependent changes of lymphocyte and granulocyte absolute numbers. A flow cytometer were used to determine major leukocyte subpopulation numbers in blood samples after red cell removal. Similar to other species, lymphocyte numbers significantly decreased in pigs both in vivo and in vitro in a dose-dependent manner. Our data clearly show that reduction of lymphocyte numbers after irradiation in vivo proceeds much faster than after irradiation in vitro and that granulocyte changes depend only on the time of analysis after irradiation. All experimental arrangements demonstrated the radiosensitivity of lymphocytes and the radioresistance of peripheral blood granulocytes. These in vivo and in vitro approaches, as well as the newly introduced ex vivo observations, appear to be relevant to biodosimetry. (en)
Title	Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo (en)
skos:prefLabel	Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo (en)
skos:notation	RIV/60162694:G44__/11:00002445!RIV12-MO0-G44_____
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B08028), P(OVUOFVZ200809), Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Pejchal, Jaroslav Zárybnická, Lenka Šinkorová, Zuzana Vávrová, Jiřina Bláha, Václav Österreicher, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ministerstvo obrany / Univerzita obrany - Fakulta vojenského zdravotnictví Hradec Králové
http://linked.open...dnocenehoVysledku	228842
http://linked.open...ai/riv/idVysledku	RIV/60162694:G44__/11:00002445
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Ionizing radiation; absolute cell count; flow cytometry; peripheral blood; pig (en)
http://linked.open.../riv/klicoveSlovo	flow cytometry absolute cell count pig Ionizing radiation peripheral blood
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9F90288E3A4F]
http://linked.open...i/riv/nazevZdroje	International Journal of Radiation Biology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	New biological methods of the received dose determination Indicators II – reverse detection of received ionizing radiation dose by monitoring of cell population changes using biophysical methods
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	87
http://linked.open...iv/tvurceVysledku	Bláha, Václav Pejchal, Jaroslav Vávrová, Jiřina Zárybnická, Lenka Šinkorová, Zuzana Šinkora, Jiří Österreicher, Jan
http://linked.open...ain/vavai/riv/wos	000289915200006
http://linked.open...n/vavai/riv/zamer	Zdravotnická problematika ZHN
issn	0955-3002
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	G44
is http://linked.open...avai/riv/vysledek of	Sensitivity of porcine peripheral blood leukocytes to gamma-irradiation in vivo, in vitro and ex vivo

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