About: Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Background. Experimental, epidemiological and clinical data substantiate the beneficial role of n-3 polyunsaturated fatty acids (PUFAs) in preventing inflammation and cancer of the colon. This review covers the unsaturated docosahexaenoic fatty acid (DHA), describes some of its important cellular and molecular mechanisms, its interaction with another dietary lipid, butyrate and with endogenous apoptotic regulators of the tumour necrosis factor (TNF) family. We also discuss the clinical impact of this knowledge and the use of these lipids in colon cancer prevention and treatment. Results. From the literature, DHA has been shown to suppress the growth, induce apoptosis in colon cancer cells in vitro and decrease the incidence and growth of experimental tumours in vivo. Based on these data and our own experimental results, we describe and discuss the possible mechanisms of DHA anticancer effects at various levels of cell organization. Background. Experimental, epidemiological and clinical data substantiate the beneficial role of n-3 polyunsaturated fatty acids (PUFAs) in preventing inflammation and cancer of the colon. This review covers the unsaturated docosahexaenoic fatty acid (DHA), describes some of its important cellular and molecular mechanisms, its interaction with another dietary lipid, butyrate and with endogenous apoptotic regulators of the tumour necrosis factor (TNF) family. We also discuss the clinical impact of this knowledge and the use of these lipids in colon cancer prevention and treatment. Results. From the literature, DHA has been shown to suppress the growth, induce apoptosis in colon cancer cells in vitro and decrease the incidence and growth of experimental tumours in vivo. Based on these data and our own experimental results, we describe and discuss the possible mechanisms of DHA anticancer effects at various levels of cell organization. (en)
Title	Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review (en)
skos:prefLabel	Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review Docosahexaenoic fatty acid (DHA) in the regulation of colon cell growth and cell death: A review (en)
skos:notation	RIV/00216224:14310/12:00067589!RIV14-MSM-14310___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GAP301/11/1730), P(GD303/09/H048), S, Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hofmanová, Jiřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	131826
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/12:00067589
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	polyunsaturated fatty acids; docosahexaenoic acid; colon cancer; apoptosis; cell signalling; anticancer therapy (en)
http://linked.open.../riv/klicoveSlovo	docosahexaenoic acid polyunsaturated fatty acids anticancer therapy apoptosis colon cancer cell signalling
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B858FCBEA50B]
http://linked.open...i/riv/nazevZdroje	BIOMEDICAL PAPERS-OLOMOUC
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mechanisms of selected pathological processes in the cell Changes of lipid metabolism and composition during colorectal carcinogenesis - the effects of butyrate and polyunsaturated fatty acids
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	156
http://linked.open...iv/tvurceVysledku	Hofmanová, Jiřina Skender, Belma Vaculová Hyršlová, Alena
http://linked.open...ain/vavai/riv/wos	000310725900001
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1213-8118
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.5507/bp.2012.093
http://localhost/t...ganizacniJednotka	14310

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