About: HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering.

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	HotSpot Wizard is a web server for automatic identification of %22hot spots%22 for engineering of substrate specificity, activity or enantioselectivity of enzymes and for annotation of protein structures. The web server implements the protein engineering protocol, which targets evolutionarily variable amino acid positions located in the active site or lining the access tunnels. The %22hot spots%22 for mutagenesis are selected through the integration of structural, functional and evolutionary information obtained from: (i) the databases RCSB PDB, UniProt, PDBSWS, Catalytic Site Atlas and nr NCBI and (ii) the tools CASTp, CAVER, BLAST, CD-HIT, MUSCLE and Rate4Site. The protein structure and e-mail address are the only obligatory inputs for the calculation. In the output, HotSpot Wizard lists annotated residues ordered by estimated mutability. The results of the analysis are mapped on the enzyme structure and visualized in the web browser using Jmol. HotSpot Wizard is a web server for automatic identification of %22hot spots%22 for engineering of substrate specificity, activity or enantioselectivity of enzymes and for annotation of protein structures. The web server implements the protein engineering protocol, which targets evolutionarily variable amino acid positions located in the active site or lining the access tunnels. The %22hot spots%22 for mutagenesis are selected through the integration of structural, functional and evolutionary information obtained from: (i) the databases RCSB PDB, UniProt, PDBSWS, Catalytic Site Atlas and nr NCBI and (ii) the tools CASTp, CAVER, BLAST, CD-HIT, MUSCLE and Rate4Site. The protein structure and e-mail address are the only obligatory inputs for the calculation. In the output, HotSpot Wizard lists annotated residues ordered by estimated mutability. The results of the analysis are mapped on the enzyme structure and visualized in the web browser using Jmol. (en)
Title	HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. (en)
skos:prefLabel	HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. (en)
skos:notation	RIV/00216224:14310/09:00028562!RIV10-MSM-14310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA201/07/0927), P(IAA401630901), P(LC06010), Z(MSM0021622412)
http://linked.open...iv/cisloPeriodika	37
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pavelka, Antonín Chovancová, Eva Damborský, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	317826
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/09:00028562
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HotSpot Wizard; hot spots; engineering of substrate specificity; activity or enantioselectivity of enzymes (en)
http://linked.open.../riv/klicoveSlovo	hot spots activity or enantioselectivity of enzymes engineering of substrate specificity HotSpot Wizard
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[00EFAE3B4AA6]
http://linked.open...i/riv/nazevZdroje	NUCLEIC ACIDS RESEARCH
http://linked.open...in/vavai/riv/obor	IN
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Evolution of substrate specificity in enzymes acting on xenobiotic compounds Center of Biocatalysis and Biotransformation Visualization of protein structures
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	2009
http://linked.open...iv/tvurceVysledku	Chovancová, Eva Damborský, Jiří Pavelka, Antonín
http://linked.open...ain/vavai/riv/wos	000267889100066
http://linked.open...n/vavai/riv/zamer	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)
issn	0305-1048
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	14310
is http://linked.open...avai/riv/vysledek of	HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering. HotSpot Wizard: a Web Server for Identification of Hot Spots in Protein Engineering.

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