About: Molecular heterogeneity and centrosome-associated genes in multiple myeloma

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis. (en)
Title	Molecular heterogeneity and centrosome-associated genes in multiple myeloma Molecular heterogeneity and centrosome-associated genes in multiple myeloma (en)
skos:prefLabel	Molecular heterogeneity and centrosome-associated genes in multiple myeloma Molecular heterogeneity and centrosome-associated genes in multiple myeloma (en)
skos:notation	RIV/00216224:14110/13:00065610!RIV14-MZ0-14110___
http://linked.open...avai/predkladatel	Lékařská fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/1395), P(NS10207), P(NT11154), P(NT13190)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kryukov, Fedor Ševčíková, Sabina Kuglík, Petr Ihnatová, Ivana Jarkovský, Jiří Hájek, Roman Němec, Pavel Kubiczková, Lenka Dementyeva, Elena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	89312
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/13:00065610
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Multiple myeloma; centrosome abnormalities; gene expression profile (en)
http://linked.open.../riv/klicoveSlovo	gene expression profile Multiple myeloma centrosome abnormalities
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D34D8773EFBB]
http://linked.open...i/riv/nazevZdroje	Leukemia & Lymphoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of chromosome 1 abnormalities and NF-kappaB cascade in patogenesis of multiple myeloma The role of B cell lineage mitotic disruptions in multiple myeloma Analysis of Clonal Plasma Cells Progenitors in Monoclonal Gammopathies Molecular signature of centrosome abnormalities and their clinical impact for patients with multiple myeloma
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Hájek, Roman Jarkovský, Jiří Kuglík, Petr Kryukov, Fedor Ševčíková, Sabina Němec, Pavel Budinská, Eva Kubiczková, Lenka Dementyeva, Elena Ihnatová, Ivana
http://linked.open...ain/vavai/riv/wos	000323492400022
issn	1042-8194
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/10428194.2013.764416
http://localhost/t...ganizacniJednotka	14110

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