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Description
| - Hemoglobin digestion is an essential process for blood-feeding parasites. We deconvoluted the hemoglobinolytic cascade in the tick Ixodes ricinus, a vector of Lyme disease and tick-borne encephalitis. A network of digestive peptidases was demonstrated through imaging with specific activity-based probes and activity profiling. Selective inhibitors were applied to dissect the roles of the individual peptidases and determine the peptidase-specific cleavage map of the hemoglobin molecule. Because of their central function in nutrition of the parasite, the identified enzymes are potential targets to developing novel anti-tick vaccines that limit parasite survival and disease transmission.
- Hemoglobin digestion is an essential process for blood-feeding parasites. We deconvoluted the hemoglobinolytic cascade in the tick Ixodes ricinus, a vector of Lyme disease and tick-borne encephalitis. A network of digestive peptidases was demonstrated through imaging with specific activity-based probes and activity profiling. Selective inhibitors were applied to dissect the roles of the individual peptidases and determine the peptidase-specific cleavage map of the hemoglobin molecule. Because of their central function in nutrition of the parasite, the identified enzymes are potential targets to developing novel anti-tick vaccines that limit parasite survival and disease transmission. (en)
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Title
| - Hemoglobin digestion in blood-feeding ticks: mapping of multipeptidase pathway by functional proteomics
- Hemoglobin digestion in blood-feeding ticks: mapping of multipeptidase pathway by functional proteomics (en)
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skos:prefLabel
| - Hemoglobin digestion in blood-feeding ticks: mapping of multipeptidase pathway by functional proteomics
- Hemoglobin digestion in blood-feeding ticks: mapping of multipeptidase pathway by functional proteomics (en)
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skos:notation
| - RIV/00216208:11310/09:10109558!RIV12-MSM-11310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - I, P(GA206/06/0865), P(IAA600960910), P(KJB400550516), P(LC06009), Z(AV0Z40550506), Z(AV0Z60220518)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11310/09:10109558
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Ixodes ricinus; tick digestion; hemoglobinolysis; active-site probes; peptidases (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Horn, Martin
- Kopáček, Petr
- Kovářová, Zuzana
- Mareš, Michael
- Sojka, Daniel
- Šanda, Miloslav
- Franta, Zdeněk
- Srba, Jindřich
- Nussbaumerová, Martina
- Caffrey, Conor R.
- Bogyo, Matthew
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.chembiol.2009.09.009
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http://localhost/t...ganizacniJednotka
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is http://linked.open...avai/riv/vysledek
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