About: Amonafide Dihydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amonafide Dihydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Amonafide Dihydrochloride
NSC_Code
  • 308847
UMLS_CUI
  • C0051733
CAS_Registry
  • 150091-68-2
In_Clinical_Trial_For
  • Prostate cancer
FDA_UNII_Code
  • 2UAV344O66
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called topoisomerase inhibitors and intercalating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40214
PDQ_Closed_Trial_Search_ID
  • 40214
Chemical_Formula
  • C16H17N3O2.2ClH
Legacy_Concept_Name
  • Amonafide
FULL_SYN
  • BenzisoquinolinedioneSYNCI
  • Amonafide HydrochlorideSYNCI
  • 1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)SNNCI
  • Amonafide DihydrochloridePTNCI
  • BIDAABNCI
  • AMONAFIDE DIHYDROCHLORIDEPTFDA2UAV344O66
  • M-FA-142CNNCI
  • QuinamedBRNCI
  • AmonafideSYNCI
  • amonafidePTNCI-GLOSSCDR0000350223
  • NafidimideSYNCI
DEFINITION
  • The dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis.NCI
code
  • C999
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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